Histone deacetylase activity is necessary for chromosome condensation during meiotic maturation in Xenopus laevis.

Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
Laura Magnaghi-Jaulin, Christian Jaulin

Abstract

Chromosome condensation is thought to be an essential step for the faithful transmission of genetic information during cellular division or gamete formation. The folding of DNA into metaphase chromosomes and its partition during the cell cycle remains a fundamental cellular process that, at the molecular level, is poorly understood. Particularly, the role of histone deacetylase (HDAC) activities in establishing and maintaining meiotic metaphase chromosome condensation has been little documented. In order to better understand how metaphase chromosome condensation is achieved during meiosis, we explored, in vivo, the consequences of HDAC activities inhibition in a Xenopus oocyte model. Our results show that deacetylase activity plays a crucial role in chromosome condensation. This activity is necessary for correct chromosome condensation since the earlier stages of meiosis, but dispensable for meiosis progression, meiosis exit and mitosis entry. We show that HDAC activity correlates with chromosome condensation, being higher when chromosomes are fully condensed and lower during interphase, when chromosomes are decondensed. In addition, we show that, unlike histone H4, Xenopus maternal histone H3 is stored in the oocyte as a hypoa...Continue Reading

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Citations

Sep 25, 2008·Zygote : the Biology of Gametes and Early Embryos·Liliana BurlibaşaLucian Gavrilă
Dec 25, 2012·Molecular and Cellular Biology·Boryana PetrovaChristian H Haering
Feb 3, 2007·The Journal of Reproduction and Development·Lian-Sheng TangShu-Ying Wang
Sep 3, 2013·Oncogene·L Bosch-Presegué, A Vaquero
Jul 19, 2008·Cancer Letters·Grégory Eot-HoullierChristian Jaulin
Jan 26, 2013·Development, Growth & Differentiation·Jun IwashitaJun Murata
Mar 17, 2010·The Plant Journal : for Cell and Molecular Biology·Giorgio PerrellaClara Conicella
Jul 1, 2008·Molecular Plant·Kingsley A BoatengChristopher A Makaroff
Jul 31, 2009·Biology of Reproduction·Iris Manosalva, Aitor González

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