Histone deacetylase function in CD4+ T cells.

Nature Reviews. Immunology
Wilfried Ellmeier, Christian Seiser

Abstract

The differentiation of T helper cell subsets and their acquisition of effector functions are accompanied by changes in gene expression programmes, which in part are regulated and maintained by epigenetic processes. Histone deacetylases (HDACs) and histone acetyltransferases (HATs) are key epigenetic regulators that function by mediating dynamic changes in the acetylation of histones at lysine residues. In addition, many non-histone proteins are also acetylated, and reversible acetylation affects their functional properties, demonstrating that HDACs mediate effects beyond the epigenetic regulation of gene expression. In this Review, we discuss studies revealing that HDACs are key regulators of CD4+ T cell-mediated immunity in mice and humans and that HDACs are promising targets in T cell-mediated immune diseases. Finally, we discuss unanswered questions and future research directions to promote the concept that isoform-selective HDAC inhibitors might broaden the clinical application of HDAC inhibitors beyond their current use in certain types of cancer.

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Citations

Aug 18, 2018·Journal of Leukocyte Biology·Lena MüllerWilfried Ellmeier
Dec 12, 2018·Expert Opinion on Investigational Drugs·Fabio Penna, Paola Costelli
Jan 24, 2019·Journal of Molecular Histology·Muwoong KimSeung Geun Yeo
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Apr 19, 2020·Seminars in Nephrology·Kelly A Hyndman
Feb 24, 2021·Journal of Autoimmunity·Patricia HammingerWilfried Ellmeier
Jul 2, 2020·Journal of Medicinal Chemistry·Terence C S HoA Ganesan
Apr 15, 2021·Cellular & Molecular Immunology·Chang H Kim
Apr 13, 2021·Frontiers in Medicine·Lorenz Gerbeth, Rainer Glauben
Apr 20, 2021·Frontiers in Immunology·Yunkai Yang, Yan Wang
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Aug 17, 2021·Frontiers in Oncology·Rihan HaiGang Yin
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Methods Mentioned

BETA
acetylation
histone acetylation
immunoprecipitation

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