Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation.

Haematologica
Marije BartelsPaul J Coffer

Abstract

The clinical use of chromatin-modulating drugs, such as histone deacetylase inhibitors, for the treatment of bone marrow failure and hematopoietic malignancies has increased dramatically over the last few years. Nonetheless, little is currently known concerning their effects on myelopoiesis. We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferation, and terminal neutrophil differentiation. Trichostatin A treatment modestly reduced progenitor proliferation, while sodium butyrate and valproic acid resulted in concentration-dependent effects on proliferation and apoptosis. Addition of valproic acid uniquely stimulated CD34(+) proliferation. Sodium butyrate treatment inhibited terminal neutrophil differentiation both quantitatively and qualitatively. Addition of 100 microM valproic acid resulted in increased numbers of mature neutrophils with a block in differentiation at increasing concentrations. Sodium butyrate and valproic acid treatment resulted in increased acetylation of histones 3 a...Continue Reading

References

Dec 1, 1987·The Journal of Experimental Medicine·D F BaintonT A Springer
Jan 1, 1997·Journal of Pediatric Hematology/oncology·K S BottomR E Ware
Aug 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Markus G ManzIrving L Weissman
May 9, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A E ChambersB D Young
Dec 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Constantine S MitsiadesKenneth C Anderson
Jan 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·J S UngerstedtP A Marks
Jan 27, 2005·Biochemical Pharmacology·Yuka SasakawaSeitaro Mutoh
Mar 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Melissa J PeartRicky W Johnstone
May 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kapil N Bhalla
Oct 6, 2005·Cell Cycle·Mario F Fraga, Manel Esteller
Jan 7, 2006·Nature Reviews. Cancer·Saverio Minucci, Pier Giuseppe Pelicci
Sep 7, 2006·Nature Reviews. Drug Discovery·Jessica E BoldenRicky W Johnstone
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Jul 25, 2007·Cancer·Andrea Kuendgen, Norbert Gattermann
Oct 16, 2007·Oncogene·K L RiceJ D Licht
Jan 10, 2008·Blood·Donald Metcalf
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Virginia M KlimekStephen D Nimer
Feb 26, 2008·Cell·Stuart H Orkin, Leonard I Zon
Mar 28, 2008·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Satoshi IidaRikiro Fukunaga

❮ Previous
Next ❯

Citations

Apr 17, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Lijing LiDavid L DiGiusto
Mar 30, 2012·Stem Cells and Development·Carina ElizaldeCésar Trigueros
Nov 12, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hanieh JafaryMasoud Soleimani
Oct 13, 2015·British Journal of Haematology·Marije BartelsMarrie Bruin
Dec 15, 2011·Experimental Cell Research·Francesca VulcanoHamisa Jane Hassan
Nov 26, 2015·The Journal of Nutritional Biochemistry·Hanying ZhangMei-Jun Zhu
Jun 2, 2014·Seizure : the Journal of the British Epilepsy Association·Sabina GuentherHajo M Hamer
Nov 19, 2013·Biological Psychiatry·Subramaniam JayanthiJean Lud Cadet
Mar 15, 2015·Blood·Adrian F Gombart
Oct 16, 2012·International Journal of Molecular Medicine·Shuai ZhangYunfei Zuo
Apr 27, 2016·Journal of Biomolecular Screening·Guruchandar ArulmozhivarmanNona Shayegi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.