Histone deacetylase inhibitor abexinostat affects chromatin organization and gene transcription in normal B cells and in mantle cell lymphoma

Gene
Diana MarkozashviliYegor Vassetzky

Abstract

Mantle cell lymphoma (MCL) is a rare lymphoma caused by the t(11:14) juxtaposing the cyclin D1 (CCND1) locus on chromosome 11 and the immunoglobulin heavy chain (IgH) locus on chromosome 14. Several new treatments are proposed for MCL, including histone deacetylase inhibitors (HDACi). We have studied gene expression and chromatin organization in the translocated 11q13 locus in MCL cells as compared to lymphoblastoid cell lines as well as the effect of HDACi abexinostat on chromatin organization and gene expression in the 11q13 locus. We have identified a cluster of genes overexpressed in the translocation region on chromosome 11 in MCL cells. Abexinostat provokes a genome-wide disaggregation of heterochromatin. The genes upregulated after the t(11;14) translocation react to the HDACi treatment by increasing their expression, but their gene promoters do not show significant alterations in H3K9Ac and H3K9me2 levels in abexinostat-treated cells.

References

Mar 9, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S StilgenbauerH Döhner
Nov 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·D KaplanK Lewandowska
Aug 7, 2002·American Journal of Clinical Pathology·Zach LiuJames Weisberger
Aug 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Xin HuangTony E Godfrey
Oct 25, 2003·Oncogene·Danyelle M Townsend, Kenneth D Tew
Jan 9, 2004·International Journal of Cancer. Journal International Du Cancer·Masanori DaibataHirokuni Taguchi
Apr 24, 2004·Critical Reviews in Eukaryotic Gene Expression·Sergey V RazinYegor S Vassetzky
May 8, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Annelise Bennaceur-GriscelliVincent Ribrag
May 25, 2004·Genes & Development·Séverine Chambeyron, Wendy A Bickmore
Jul 21, 2004·Cancer Cell·Minna AllinenKornelia Polyak
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Timothy C GreinerJoseph G Hacia
Sep 7, 2006·Nature Reviews. Drug Discovery·Jessica E BoldenRicky W Johnstone
Sep 12, 2006·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yuxin JiDing Ma
Sep 4, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T AraiS Noguchi
Oct 29, 2008·Hematology/oncology Clinics of North America·Christian Schmidt, Martin Dreyling
Mar 10, 2010·Genome Research·Louise HarewoodAlexandre Reymond
Jul 8, 2011·Nature Reviews. Cancer·Elizabeth A MusgroveRobert L Sutherland
Jan 1, 2010·Arthritis·Ruby Alonso-RamirezYves Renaudineau
Dec 14, 2011·Carcinogenesis·Arnaud Van Den BroeckSylvie Gazzeri
Jun 8, 2012·The Journal of Investigative Dermatology·Guangdi ChenGang Li
Oct 27, 2012·Expert Review of Anticancer Therapy·Valérie Camara-ClayetteVincent Ribrag
Feb 13, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Da-Wei ChenXiao-Xiao Jiang
Nov 30, 2013·Human Molecular Genetics·Martine Chevillard-BrietFabrice Escaffit
Jan 3, 2014·The Journal of Clinical Investigation·Alison C West, Ricky W Johnstone
Jun 20, 2014·FEBS Letters·Cristina Escoda-FerranFrancisco Lozano
Sep 13, 2014·Cell Death and Differentiation·K S R SastryL Chouchane
Nov 15, 2014·Cancer Metastasis Reviews·Kyle R Covington, Suzanne A W Fuqua

❮ Previous
Next ❯

Citations

Feb 1, 2019·Journal of Cellular Physiology·Fatimata Bintou SallDiego Germini

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

© 2022 Meta ULC. All rights reserved