Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites

Biochemical and Biophysical Research Communications
Soyoung KimJeung-Whan Han

Abstract

We show that a histone deacetylase (HDAC) inhibitor apicidin increases the transcriptional activity of cyclin E gene, which results in accumulation of cyclin E mRNA and protein in a time- and dose-dependent manner. Interestingly, apicidin induction of cyclin E gene is found to be mediated by Sp1- rather than E2F-binding sites in the cyclin E promoter, as evidenced by the fact that specific inhibition of Sp1 leads to a decrease in apicidin activation of cyclin E promoter activity and protein expression, but mutation of E2F-binding sites of cyclin E promoter region fails to inhibit the ability of apicidin to activate cyclin E transcription. In addition, this transcriptional activation of cyclin E by apicidin is associated with histone hyperacetylation of cyclin E promoter region containing Sp1-binding sites. Our results demonstrate that regulation of histone modification by an HDAC inhibitor apicidin contributes to induction of cyclin E expression and this effect is Sp1-dependent.

References

Mar 9, 1995·Nature·D O Morgan
Apr 1, 1996·Molecular and Cellular Biology·J KarlsederE Wintersberger
Apr 1, 1996·Molecular and Cellular Biology·S Y LinJ C Azizkhan
Jul 1, 1996·Molecular and Cellular Biology·J BotzP Jansen-Dürr
Nov 26, 1999·Gene·G Suske
Jan 19, 2000·Nature·B D Strahl, C D Allis
Apr 17, 2001·Experimental Cell Research·P D GregoryW Hörz
Jun 8, 2001·Journal of the Society for Gynecologic Investigation·T SawasakiK Ohama
Mar 6, 2002·The Journal of Biological Chemistry·Seijiro TaniuraThomas E Eling
Mar 15, 2002·Current Opinion in Genetics & Development·Shelley L Berger
Mar 16, 2002·Oncogene·Edgar GrinsteinHans-Dieter Royer

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Citations

Dec 7, 2007·Clinical & Experimental Metastasis·Denis Mottet, Vincent Castronovo
May 2, 2009·Archives of Pharmacal Research·Su-Nam KimYong Kee Kim
Jan 12, 2013·Cellular Oncology (Dordrecht)·Anna Algamas-DimantovBetty Schwartz
Oct 4, 2007·Biochemical and Biophysical Research Communications·Gong-Hong WeiChih-Chuan Liang
Apr 14, 2010·The Journal of Biological Chemistry·Vaibhao C JanbandhuVijay Kumar
Jun 10, 2010·Anti-cancer Drugs·Marta Durczak, Paweł Piotr Jagodzinski
Sep 5, 2008·American Journal of Physiology. Cell Physiology·Beiyun ZhouZea Borok
Jan 5, 2012·The Journal of Clinical Investigation·Floriana ForzatiAlfredo Fusco
May 20, 2009·Journal of Neuroinflammation·Xianrong R MaoSteven W Barger
Jan 10, 2013·PloS One·Jianjun XiongWeidong Li
Dec 7, 2007·International Journal of Hematology·Yasuhiro Oki, Jean-Pierre J Issa
Jul 15, 2015·Biomedical Reports·Jianjun XiongWeidong Li
Nov 11, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Szymon Debicki, Paweł P Jagodzinski
Apr 12, 2008·Journal of Cellular Biochemistry·Sangita RoyW Jackson Pledger
Sep 10, 2011·Journal of Radiation Research·Tadashi TsuchimotoMasato Hareyama
Jun 22, 2020·FEBS Letters·Betheney R Pennycook, Alexis R Barr
Nov 8, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyun Myung KoChan Young Shin

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