Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines

Molecular Carcinogenesis
Erika Contreras-LealJuan Santiago-García

Abstract

Recent studies have shown that expression of Sarco(endo)plasmic Reticulum Ca(2+) -ATPase 2 (SERCA2) is decreased in oral cancer; whereas expression of SERCA3 is considerably decreased or absent in human colon, gastric, breast, and lung cancers. The ATP2A2 and ATP2A3 genes encode SERCA2 and SERCA3 isoforms, respectively. Promoter methylation on CpG islands was responsible for the repression of ATP2A2 gene in human oral cancer samples. On the other hand, histone deacetylase inhibitors (HDACi) up-regulate ATP2A3 expression in gastric, colon, and lung cancer cells in culture, however, the molecular mechanism is unknown. In this study, we investigate whether HDACi and DNA methylation regulate ATP2A2 and ATP2A3 expression in human breast cancer cell lines. Results show a marked induction of SERCA3a and pan-SERCA3 mRNA expression in human MCF-7 and MDA-MB-231 cells treated with sodium butyrate (NaB) or trichostatin A (TSA); whereas SERCA2b mRNA expression did not change significantly. ChIP assays show that NaB or TSA treatment of MDA-MB-231 cells increases H3K9 acetylation on ATP2A3 promoter. NaB also decreases H3K9 trimethylation; suggesting that these modifications stimulate ATP2A3 gene expression, through a chromatin remodeling mec...Continue Reading

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Citations

Oct 23, 2016·Free Radical Biology & Medicine·Christophe GlorieuxPedro Buc Calderon
Feb 6, 2017·Molecular Carcinogenesis·Eduardo Izquierdo-TorresAngel Zarain-Herzberg
Jan 19, 2019·Molecular Carcinogenesis·Iván Meneses-MoralesÁngel Zarain-Herzberg
Jun 28, 2018·Pathology Oncology Research : POR·Pingping GuoLisha Li
Mar 19, 2020·Nutrients·Priyanga SelvakumarAshakumary Lakshmikuttyamma
May 14, 2020·International Journal of Molecular Sciences·Bela PappHoma Adle-Biassette
Jun 13, 2020·Frontiers in Neuroscience·Sandra M Díaz-RodríguezDolores E Lopéz
Jan 6, 2021·Journal of Cell Communication and Signaling·Andrés Hernández-OliverasJuan Santiago-García

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