Histone deacetylase inhibitors regulate p21WAF1 gene expression at the post-transcriptional level in HepG2 cells

FEBS Letters
Calley L Hirsch, Keith Bonham

Abstract

Histone deacetylase inhibitors (HDIs) are thought to act primarily at the level of transcription inducing cell cycle arrest, differentiation and/or apoptosis in many cancer cell types. Induction of the potent cdk/cyclin inhibitor p21WAF1 is a key feature of this HDI mediated transcriptional re-programming phenomenon. However, in the current study we report that HDIs are also capable of inducing p21WAF1 through purely post-transcriptional events, namely increased mRNA stability. These studies highlight our growing appreciation for the complexities of HDI mediated effects and challenge our preconceptions regarding the action of these promising anti-neoplastics.

References

May 1, 1978·Cell·L Sealy, R Chalkley
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·S Y ArcherR A Hodin
Nov 12, 1998·Journal of the National Cancer Institute·R P WarrellP P Pandolfi
Jan 11, 2000·Molecular and Cellular Biology·W WangM Gorospe
Mar 16, 2000·The EMBO Journal·T Kouzarides
Aug 3, 2000·Journal of the National Cancer Institute·P A MarksR A Rifkind
Aug 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·V M RichonP A Marks
Sep 9, 2000·The Journal of Biological Chemistry·K BonhamF M Boyd
Mar 27, 2002·Anti-cancer Drugs·David M Vigushin, R Charles Coombes
Oct 8, 2003·Current Medicinal Chemistry·Janine ArtsKristof Van Emelen

❮ Previous
Next ❯

Citations

Jun 14, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Iva B Zovkic, J David Sweatt
Sep 11, 2008·Expert Opinion on Therapeutic Targets·Brian R Keppler, Trevor K Archer
Jan 9, 2008·Biochemical and Biophysical Research Communications·D J P EllisK Bonham
Jan 30, 2015·Molecular BioSystems·Gunjan S ThakurFrancis J Doyle
Aug 12, 2005·International Journal of Cancer. Journal International Du Cancer·Calley L HirschKeith Bonham
Feb 22, 2005·Journal of Cellular Biochemistry·Paula S EspinoJames R Davie
Feb 16, 2008·Journal of Cellular Biochemistry·Jung-Hoon KangYang-Hyeok Jo
Dec 18, 2009·British Journal of Pharmacology·Pritika Narayan, Mike Dragunow
Jan 26, 2013·Development, Growth & Differentiation·Jun IwashitaJun Murata
Jul 29, 2015·World Journal of Gastroenterology : WJG·Yu-Gang WangMin Shi
Jun 18, 2010·Expert Review of Anticancer Therapy·Brahma N SinghShi-Wen Jiang
Apr 14, 2010·Biochemical Pharmacology·Wei WangFrank M Torti
Sep 23, 2008·The International Journal of Biochemistry & Cell Biology·Stephanie SpangeOliver H Krämer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis