Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury

Journal of Pharmacological Sciences
H UchidaHiroshi Ueda

Abstract

Neuropathic pain is often insensitive to morphine. Our previous study has demonstrated that neuron-restrictive silencer factor represses mu opioid receptor (MOP) gene expression in the dorsal root ganglion (DRG) via histone hypoacetylation-mediated mechanisms after peripheral nerve injury, thereby causing loss of peripheral morphine analgesia. Here, we showed that histone deacetylase (HDAC) inhibitors, such as trichostatin A and valproic acid, restored peripheral and systemic morphine analgesia in neuropathic pain. Also, these agents blocked nerve injury-induced MOP down-regulation in the DRG. These results suggest that HDAC inhibitors could serve as adjuvant analgesics to morphine for the management of neuropathic pain.

References

Jan 14, 2004·The Journal of Pharmacology and Experimental Therapeutics·Md Harunor RashidHiroshi Ueda
Jun 19, 2007·Nature Reviews. Genetics·Lezanne Ooi, Ian C Wood
Apr 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hitoshi UchidaHiroshi Ueda
Jul 24, 2010·Lancet Neurology·Ralf BaronGunnar Wasner
Sep 8, 2010·Neuroscience Letters·Tamae DobashiTomohiko Aoe
Sep 17, 2013·British Journal of Pharmacology·Yosuke MatsushitaHiroshi Ueda

❮ Previous
Next ❯

Citations

Oct 27, 2016·Neuroscience·Laurie-Anne RoeckelFrédéric Simonin
Dec 26, 2016·Peptides·Richard J Bodnar
Oct 16, 2018·European Journal of Pain : EJP·Miriam Martínez-NavarroJosep-E Baños
Jan 11, 2019·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Ravneet Kaur KhanguraAmteshwar Singh Jaggi
Jun 23, 2018·Frontiers in Cellular Neuroscience·Clara Penas, Xavier Navarro
Dec 24, 2018·Brain Sciences·Ryan Thompson, Christina Chan
Nov 27, 2021·Molecular Pain·Danzhi LuoJun Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.