Histone Deacetylases SRT1 and SRT2 Interact with ENAP1 to Mediate Ethylene-Induced Transcriptional Repression

The Plant Cell
Fan ZhangHong Qiao

Abstract

Ethylene plays pleiotropic roles in plant growth, plant development, and stress responses. Although the effects of ethylene on plants are well documented, little is known about molecular-level events that result in transcriptional repression during the ethylene response. In this study, we found that two histone deacetylases, SRT1 and SRT2, interact with ENAP1, which associates with EIN2 in the nucleus. Genetic and transcriptome analyses revealed that SRT1 and SRT2 are required for negative regulation of certain ethylene-responsive genes. The acetylation of HISTONE3 at K9 (H3K9Ac) is specifically regulated by SRT1 and SRT2 in ethylene-repressed genes. In addition, the srt1 srt2 double mutation in Arabidopsis thaliana suppresses both the ENAP1ox and the EIN3ox constitutive ethylene response phenotypes, and the ethylene-induced transcriptional repression observed in EIN3ox plants is derepressed in the EIN3ox/srt1 srt2 mutant. SRT2 and ENAP1 both bind to promoter regions of genes negatively regulated by ethylene, reducing H3K9Ac levels and resulting in transcriptional repression. This work establishes a mechanism by which histone deacetylases SRT1 and SRT2 interact with ENAP1 to mediate transcriptional repression by regulating the ...Continue Reading

Citations

Apr 26, 2020·Journal of Experimental Botany·Jianjun JiangXuehua Zhong
Jul 6, 2019·Frontiers in Plant Science·Likai Wang, Hong Qiao
Dec 28, 2019·Science China. Life Sciences·Xiangsong ChenXuehua Zhong
Jul 6, 2020·Plant Molecular Biology·Jing-Bo ZhangXue-Bao Li
May 5, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Karin KrupinskaMichela Zottini
Sep 12, 2019·Frontiers in Plant Science·Vladislav A DolgikhElena V Zemlyanskaya
Apr 26, 2020·The Journal of Biological Chemistry·Brad M Binder
Oct 24, 2020·Journal of Integrative Plant Biology·He ZhaoJin-Song Zhang
Nov 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Likai WangHong Qiao
Feb 28, 2021·Cellular and Molecular Life Sciences : CMLS·Verandra KumarManoj Prasad
May 11, 2020·Plant Physiology and Biochemistry : PPB·Md Imdadul HaqDhirendra Kumar
Apr 24, 2021·Transgenic Research·S Selma, D Orzáez
May 27, 2021·Plant Science : an International Journal of Experimental Plant Biology·Núria Vall-LlauraJordi Giné-Bordonaba
Aug 25, 2021·Trends in Plant Science·Elias Feitosa-AraujoAdriano Nunes-Nesi
Sep 30, 2021·The Plant Journal : for Cell and Molecular Biology·Han XuFan Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.