Histone deacetylation meets miRNA: epigenetics and post-transcriptional regulation in cancer and chronic diseases

Expert Opinion on Biological Therapy
Stefan SwierczynskiDaniel Neureiter

Abstract

Epigenetic regulation via DNA methylation, histone acetylation, as well as by microRNAs (miRNAs) is currently in the scientific focus due to its role in carcinogenesis and its involvement in initiation, progression and metastasis. While many target genes of DNA methylation, histone acetylation and miRNAs are known, even less information exists as to how these mechanisms cooperate and how they may regulate each other in a specific pathological context. For further development of therapeutic approaches, this review presents the current status of the crosstalk of histone acetylation and miRNAs in human carcinogenesis and chronic diseases. This article reviews information from comprehensive PubMed searches to evaluate relevant literature with a focus on possible association between histone acetylation, miRNAs and their targets. Our analysis identified specific miRNAs which collaborate with histone deacetylases (HDACs) and cooperatively regulate several relevant target genes. Fourteen miRNAs could be linked to the expression of eight HDACs influencing the α-(1,6)-fucosyltransferase, polycystin-2 and the fibroblast-growth-factor 2 pathways. Focusing on the complex linkage of miRNA and HDAC expression could give deeper insights in new...Continue Reading

References

Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·B E BernsteinS L Schreiber
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Amaia LujambioManel Esteller
Oct 1, 2008·Cancer Letters·Olaf WittIna Oehme
Jun 1, 2007·Molecular Oncology·Santiago Ropero, Manel Esteller
Feb 20, 2010·Obstetrics and Gynecology International·Noriyuki Takai, Hisashi Narahara
Mar 10, 2010·Cancer Treatment and Research·Dennis P M Hughes
Jun 24, 2010·The EMBO Journal·Roel H WiltingJan-Hermen Dannenberg
Oct 26, 2010·Biochimica Et Biophysica Acta·Xiaogang Li
Jan 13, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shiro MizunoNorbert F Voelkel
Feb 18, 2011·The Journal of Biological Chemistry·Catherine E WinbanksPaul Gregorevic
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 2, 2011·Journal of Biomedicine & Biotechnology·Sebastian StintzingDaniel Neureiter
Dec 20, 2011·World Journal of Gastroenterology : WJG·Xiao-Feng YuJie Dong
Feb 7, 2012·Blood·Clemens M Wendtner
Mar 16, 2012·Future Medicinal Chemistry·Berkley E GryderAdegboyega K Oyelere
Sep 12, 2012·Molecular Oncology·Bruna Barneda-Zahonero, Maribel Parra
Sep 18, 2012·Bioorganic & Medicinal Chemistry Letters·Sreerangam N C V L PushpavalliManika Pal-Bhadra
Oct 2, 2012·International Journal of Cancer. Journal International Du Cancer·Hedwig E DeubzerOlaf Witt
Nov 13, 2012·Molecular Oncology·Maria NewNicholas B La Thangue
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sukhinder K SandhuCarlo M Croce
Dec 6, 2012·Molecular BioSystems·Matthew J Hynes, Joshua A Maurer
Jan 5, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·David KaluzaStefanie Dimmeler
Feb 15, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Yasufumi Sato
Mar 8, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Michael J Morris, Lisa M Monteggia
Apr 30, 2013·Nucleic Acids Research·Marco LodriniHedwig E Deubzer
Jun 14, 2013·Proceedings of the National Academy of Sciences of the United States of America·Vishal PatelPeter Igarashi
Jun 25, 2013·Molecular Cell·Christopher J MillardJohn W R Schwabe

❮ Previous
Next ❯

Citations

Jun 13, 2015·Journal of Diabetes Research·Gabriele TogliattoMaria Felice Brizzi
Dec 14, 2018·International Journal of Molecular Sciences·Maria MrakovcicLeopold F Fröhlich
Mar 7, 2019·American Journal of Physiology. Cell Physiology·Qingyi MaWilliam J Pearce
Aug 8, 2015·The European Respiratory Journal·Emmanuel T OseiCorry-Anke Brandsma
Oct 28, 2019·International Journal of Molecular Sciences·Eckhard KlieserMatthias Ocker
Mar 18, 2016·International Journal of Molecular Medicine·Xiaochen FanXuesong Chen
May 18, 2017·Genes·Elisabeth Naderlinger, Klaus Holzmann
Jun 19, 2017·Journal of Hematology & Oncology·Nasrin RastgooHong Chang
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Jun ZhaoMatthew W Lawless
Jan 2, 2019·International Journal of Molecular Sciences·Antonios N GargalionisAthanasios G Papavassiliou
Sep 19, 2018·International Journal of Molecular Sciences·Eckhard KlieserDaniel Neureiter
Sep 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fatemeh MemariNosratollah Zarghami

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

© 2021 Meta ULC. All rights reserved