Aug 22, 2006

Histone demethylation and androgen-dependent transcription

Current Opinion in Genetics & Development
Eric MetzgerRoland Schüle


Covalent modifications of histones play important roles in the regulation of chromatin dynamics and gene activity. Until recently, it was believed that methyl groups could not be removed from histones; as such, the discovery of the first demethylases opens a novel era in understanding how chromatin dynamic is regulated and shows that active demethylation is linked to both transcriptional repression and activation. During androgen-dependent gene activation, specific demethylases are involved in the control of gene expression. These new findings represent a milestone in elucidating the function of demethylases in gene expression. Furthermore, they show that active demethylation of repressive histone marks is a hallmark in the control of specific gene expression.

  • References17
  • Citations17

Mentioned in this Paper

Prostatic Neoplasms
Androgen Receptor
Covalent Interaction
Transcriptional Regulation
Histone antigen
Androgen Effect
Transcription Repressor/Corepressor
Histone Arginine Demethylases
Protein Methylation
Complex (molecular entity)

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