PMID: 2499687Apr 1, 1989Paper

Histone genes in Physarum polycephalum: transcription and analysis of the flanking regions of the two H4 genes

Journal of Molecular Evolution
M L Wilhelm, F X Wilhelm

Abstract

The histone H4 multigene family of Physarum polycephalum consists of two genes, H41 and H42. Both genes have an unusual structure in that they are interrupted by a small intron. The structure of the P. polycephalum H4 genes is discussed and compared to the structure of histone genes of other organisms. S1 nuclease analysis was used to map the 5' and 3' ends of the histone H4 messengers. We show that the histone H4 genes have a hybrid structure; they are interrupted by an intervening sequence, as in replacement variant histone genes of higher eukaryotes, but their 5' and 3' noncoding regions have the properties of replication-dependent histone genes: the 5' and 3' leader and trailer sequences are short, possess a 3'-hyphenated dyad symmetry element, and a CAGA sequence is found 3' to the hyphenated hairpin structure. This report also provides evidence that both genes are expressed in late G2 phase as well as in S phase and that their expression is temporally coordinated and quantitatively similar during the cell cycle.

References

Jun 1, 1985·Molecular and Cellular Biology·D BrushJ D Engel
Jul 1, 1985·Molecular and Cellular Biochemistry·D CollartJ L Stein
May 31, 1988·Biochemical and Biophysical Research Communications·M L WilhelmF X Wilhelm
Dec 1, 1986·Computer Methods and Programs in Biomedicine·R O Davis
Jul 10, 1987·Nucleic Acids Research·M L Wilhelm, F X Wilhelm
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R JalouzotF X Wilhelm
Apr 1, 1982·Cell·D A Clayton
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D B SittmanW F Marzluff
Aug 1, 1982·Cell·L HerefordM A Osley
Jan 1, 1982·Annals of the New York Academy of Sciences·E A RachmilewitzM Acker
Aug 1, 1981·Cell·C C Hentschel, M L Birnstiel

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Citations

Apr 1, 1992·Journal of Molecular Evolution·M A HuynenP Hogeweg
Feb 28, 1997·Biochimica Et Biophysica Acta·P Wyler-DudaD Schümperli
Apr 25, 1991·Nucleic Acids Research·D Wells, D Brown
Jun 1, 1990·General and Comparative Endocrinology·C Dauphin-VillemantH Vaudry

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