Histone hyperacetylation and exon skipping: a calcium-mediated dynamic regulation in cardiomyocytes

Nucleus
Alok SharmaHua Lou

Abstract

In contrast to cell type-specific pre-mRNA alternative splicing, mechanisms controlling activity-dependent alternative splicing is under-studied and not well understood. In a recent study, we conducted a comprehensive analysis of calcium-mediated mechanism that regulates alternative exon skipping in mouse cardiomyocytes. Our results reveal a strong link between histone hyperacetylation and skipping of cassette exons, and provide support to the kinetic coupling model of the epigenetic regulation of alternative splicing at the chromatin level.

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Methods Mentioned

BETA
ChIP
histone acetylation
acetylation

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