Histone methylation-associated transgenerational inheritance of reproductive defects in Caenorhabditis elegans exposed to crude oil under various exposure scenarios

Chemosphere
Jisu YangJinhee Choi

Abstract

As part of a study to explore the long-term effects of the Hebei Spirit oil spill accident, transgenerational toxicity and associated epigenetic changes were investigated in the nematode Caenorhabditis elegans. Under experimental conditions, worms were exposed to Iranian heavy crude oil (IHC) under three different scenarios: partial early-life exposure (PE), partial late-life exposure (PL), and whole-life exposure (WE). Growth, reproduction, and histone methylation were monitored in the exposed parental worms (P0) and in three consecutive unexposed offspring generations (F1-3). Reproductive potential in the exposed P0 generation in the WE treatment group was reduced; additionally, it was inhibited in the unexposed offspring generations of the P0 worms. This suggests that there was transgenerational inheritance of defective reproduction. Comparison of developmental periods of exposure showed that IHC-treated worms in the PL group had a greater reduction in reproductive capacity than those in the PE group. Decreased methylation of histone H3 (H3K9) was found in the IHC-exposed parental generation. A heritable reduction in reproductive capacity occurred in wildtype N2 but was not found in a H3K9 histone methyltransferase (HMT) mut...Continue Reading

Citations

Jul 6, 2020·The Journal of Experimental Biology·Naim M BautistaWarren Burggren
Dec 19, 2019·Frontiers in Endocrinology·Ziqiang ZhuXiaozhong Li
Oct 6, 2018·Environmental Health and Toxicology·Nivedita ChatterjeeJinhee Choi
Apr 15, 2020·Ecotoxicology and Environmental Safety·Ana De la Parra-GuerraJesus Olivero-Verbel
Jun 11, 2021·The Science of the Total Environment·Huanliang LiuDayong Wang

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