PMID: 1201615Dec 1, 1975Paper

Histone modification in liver after administration of inducers of mixed function oxidase activity

Chemico-biological Interactions
R L Procaccini, E Bresnick

Abstract

The phosphorylation and acetylation of rat liver histones in vivo were determined after administration of phenobarbital or 3-methylcholanthrene. No changes were observed in the phosphorylation profile of histones separated by gel electrophoresis after treatment with either of these two inducing agents. However, after 2h of treatment with either phenobarbital or 3-methylcholanthrene, a significant increase in acetylation of histones was noted, particularly in the F2a1 and (F3, F2b, F2a2) regions. It is suggested that this increase which precedes the enhancement in RNA synthesis may play a role in the alteration of transcription in liver.

References

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Citations

Jan 1, 1976·Annals of the New York Academy of Sciences·S J SmithE S Vesell
Jun 19, 2003·British Journal of Pharmacology·Michael MurrayDylan Sutton
Dec 30, 1975·Annals of the New York Academy of Sciences·A E Shamoo, T E Ryan
Mar 1, 1976·Chemico-biological Interactions·K D Lanclos, E Bresnick
Aug 14, 1978·Biochemical and Biophysical Research Communications·J P MacGregorM R Hall

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