Histone modifications as a pathogenic mechanism of colorectal tumorigenesis

The International Journal of Biochemistry & Cell Biology
Antonios N GargalionisAthanasios G Papavassiliou

Abstract

Epigenetic regulation of gene expression has provided colorectal cancer (CRC) pathogenesis with an additional trait during the past decade. In particular, histone post-translational modifications set up a major component of this process dictating chromatin status and recruiting non-histone proteins in complexes formed to "handle DNA". In CRC, histone marks of aberrant acetylation and methylation levels on specific residues have been revealed, along with a plethora of deregulated enzymes that catalyze these reactions. Mutations, deletions or altered expression patterns transform the function of several histone-modifying proteins, further supporting the crucial role of epigenetic effectors in CRC oncogenesis, being closely associated to inactivation of tumor suppressor genes. Elucidation of the biochemical basis of these new tumorigenic mechanisms allows novel potential prognostic factors to come into play. Moreover, the detection of these changes even in early stages of the multistep CRC process, along with the reversible nature of these mechanisms and the technical capability to detect such alterations in cancer cells, places this group of covalent modifications as a further potential asset for clinical diagnosis or treatment o...Continue Reading

References

Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·S Y ArcherR A Hodin
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
Jun 11, 1999·The Journal of Biological Chemistry·M E BradyC N Robson
Feb 17, 2000·The EMBO Journal·M A Martínez-BalbásT Kouzarides
Feb 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·R B ChadwickA de la Chapelle
Mar 4, 2000·Nature Genetics·S A GaytherC Caldas
Oct 12, 2000·Cellular and Molecular Life Sciences : CMLS·A J Bannister, E A Miska
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·F Magdinier, A P Wolffe
Oct 10, 2001·The Journal of Biological Chemistry·L GaughanC N Robson
Oct 11, 2002·Nature·Sooryanarayana VaramballyArul M Chinnaiyan
Oct 18, 2002·International Journal of Cancer. Journal International Du Cancer·Emma J BryanIan G Campbell
Apr 4, 2003·Cancer Biology & Therapy·Penny K Davis, Rainer K Brackmann
May 31, 2003·EMBO Reports·Scott R FrankBruno Amati
Aug 2, 2003·Cancer Cell·Ricky W Johnstone, Jonathan D Licht
Nov 25, 2003·The New England Journal of Medicine·James G Herman, Stephen B Baylin
Jan 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yurij IonovJohn K Cowell
Feb 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A EmterlingX-F Sun
May 18, 2004·Cancer Cell·Ping ZhuMartin Göttlicher
May 18, 2004·Genes & Development·Gunnar SchottaThomas Jenuwein
May 25, 2004·Oncogene·Narayanan Gopalakrishna IyerCarlos Caldas
Jul 3, 2004·Genes & Development·Antonis KirmizisPeggy J Farnham
Jul 6, 2004·Nature Cell Biology·Ryuji HamamotoYusuke Nakamura
Jul 23, 2004·Current Biology : CB·Craig L Peterson, Marc-André Laniel
Oct 14, 2004·Endocrine Reviews·David Y LeeMichael R Stallcup
Nov 4, 2004·Nature Structural & Molecular Biology·Michael S CosgroveCynthia Wolberger
Nov 30, 2004·Science·Nicole J FrancisChristopher L Woodcock
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Andrei KuzmichevDanny Reinberg
Apr 20, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K MimoriM Mori
Oct 18, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Helena Santos-Rosa, Carlos Caldas
Nov 2, 2005·Nature Reviews. Molecular Cell Biology·Cyrus Martin, Yi Zhang

❮ Previous
Next ❯

Citations

Sep 28, 2013·Nature Genetics·Travis I ZackRameen Beroukhim
Jun 5, 2013·International Journal of Cancer. Journal International Du Cancer·Antonios N GargalionisAthanasios G Papavassiliou
Aug 4, 2015·Pharmacogenomics·Elena Puerta-GarcíaMiguel Ángel Calleja-Hernández
May 17, 2014·Chemical Reviews·Vladimir N UverskyAndreas C Joerger
Feb 13, 2019·Journal of Applied Toxicology : JAT·Gabriela M ChiocchettiVicenta Devesa
May 6, 2019·Pathology Oncology Research : POR·Jingchun QinHuixuan Li
May 30, 2014·Expert Review of Gastroenterology & Hepatology·Fabio Coppedè
Jan 5, 2020·Nature Reviews. Gastroenterology & Hepatology·Gerhard JungAjay Goel
Jul 19, 2018·The Oncologist·Alberto PucciniMohamed E Salem
Feb 4, 2019·Current Treatment Options in Gastroenterology·Anand Venugopal, Elena M Stoffel
Jan 29, 2013·International Journal of Oncology·Katsuya OhtaHideshi Ishii
May 22, 2018·Frontiers in Genetics·April L Darling, Vladimir N Uversky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics Chromatin Complexes (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin complexes and their role in cancer epigenetics.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics and Chromatin (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin and its role in cancer epigenetics please follow this feed to learn more.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.