Histone modifications in DNA damage response

Science China. Life Sciences
Lin-Lin CaoWei-Guo Zhu

Abstract

DNA damage is a relatively common event in eukaryotic cell and may lead to genetic mutation and even cancer. DNA damage induces cellular responses that enable the cell either to repair the damaged DNA or cope with the damage in an appropriate way. Histone proteins are also the fundamental building blocks of eukaryotic chromatin besides DNA, and many types of post-translational modifications often occur on tails of histones. Although the function of these modifications has remained elusive, there is ever-growing studies suggest that histone modifications play vital roles in several chromatin-based processes, such as DNA damage response. In this review, we will discuss the main histone modifications, and their functions in DNA damage response.

References

Apr 16, 1998·The Journal of Biological Chemistry·E P RogakouW M Bonner
Sep 9, 1999·The Journal of Cell Biology·E P RogakouW M Bonner
Jan 19, 2000·Nature·B D Strahl, C D Allis
Mar 16, 2000·The EMBO Journal·T Kouzarides
Jan 5, 2001·Nature·J A DownsS P Jackson
Jun 8, 2001·Annual Review of Biochemistry·S Y RothC D Allis
Jun 8, 2001·Annual Review of Biochemistry·C M Pickart
Oct 24, 2001·The Journal of Biological Chemistry·I M Ward, J Chen
Apr 6, 2002·Science·Arkady CelesteAndré Nussenzweig
May 30, 2002·Proceedings of the National Academy of Sciences of the United States of America·Craig H BassingFrederick W Alt
Sep 28, 2002·Nature·Alexander W BirdMichael F Christman
Nov 6, 2002·Molecular and Cellular Biology·Song Qin, Mark R Parthun
Jun 7, 2003·Nature Cell Biology·Arkady CelesteAndré Nussenzweig
Aug 14, 2003·Cell·Arkady CelesteAndré Nussenzweig
Jan 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ali JazayeriStephen P Jackson
Jun 11, 2004·Annual Review of Biochemistry·Aziz SancarStuart Linn
Jun 16, 2004·The Journal of Experimental Medicine·Oscar Fernandez-CapetilloAndré Nussenzweig
Nov 5, 2004·Nature·Yentram HuyenThanos D Halazonetis
Dec 22, 2004·Molecular Cell·Anyong XieRalph Scully
Jan 6, 2005·The Journal of Biological Chemistry·Michele GiannattasioMarco Muzi-Falconi
Jun 1, 2005·Molecular and Cellular Biology·Arun GuptaTej K Pandita
Sep 17, 2005·Molecular and Cellular Biology·Robert WysockiStephen J Kron
Dec 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Suk-Hee LeeRobert Hromas

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Citations

May 25, 2016·Acta Biochimica Et Biophysica Sinica·Yongcan Chen, Wei-Guo Zhu
Jun 1, 2016·Genomics, Proteomics & Bioinformatics·Ting Liu, Jun Huang
Nov 6, 2018·Cell Cycle·Hieu T Van, Margarida A Santos
Jul 14, 2019·Clinical Epigenetics·Yorick JanssensBart De Spiegeleer
Feb 12, 2020·Scientific Reports·Donna J LoweStephen P Jackson
Dec 14, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Veronick BenoyLudo Van Den Bosch
Jun 8, 2017·Oncology Letters·Gabriela Figueroa-González, Carlos Pérez-Plasencia
Oct 30, 2020·Frontiers in Cell and Developmental Biology·Guo LiWei-Guo Zhu
Mar 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaopeng LuWei-Guo Zhu
Jun 9, 2021·Experimental Cell Research·Eleanor Rachel Stead, Ivana Bjedov
Sep 7, 2021·Frontiers in Cellular and Infection Microbiology·Tianshu SunYingchun Xu
Oct 8, 2021·Frontiers in Cell and Developmental Biology·Zuobing ChenXiaosheng Wang

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