Histone Variant H3.3: A versatile H3 variant in health and in disease

Science China. Life Sciences
Chaoyang XiongGuohong Li

Abstract

Histones are the main protein components of eukaryotic chromatin. Histone variants and histone modifications modulate chromatin structure, ensuring the precise operation of cellular processes associated with genomic DNA. H3.3, an ancient and conserved H3 variant, differs from its canonical H3 counterpart by only five amino acids, yet it plays essential and specific roles in gene transcription, DNA repair and in maintaining genome integrity. Here, we review the most recent insights into the functions of histone H3.3, and the involvement of its mutant forms in human diseases.

References

Nov 20, 1995·Genomics·W AlbigD Doenecke
Apr 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sandra B HakeC David Allis
Jun 10, 2005·FEBS Letters·Tobias StraubPeter B Becker
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Steven Henikoff, Kami Ahmad
Feb 27, 2007·Cell·Tony Kouzarides
Mar 10, 2007·Science·Yoshiko MitoSteven Henikoff
Dec 18, 2008·Genome Research·Steven HenikoffKami Ahmad
Apr 20, 2010·Nature Structural & Molecular Biology·Alessandro VezzoliMark Bycroft
Jun 16, 2010·The Journal of Biological Chemistry·Arunkumar DhayalanAlbert Jeltsch
Jul 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Peter W LewisC David Allis
Aug 3, 2010·Nature Cell Biology·Angèle SantenardMaria-Elena Torres-Padilla
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jae-Hyun YangEun-Jung Cho
Jan 26, 2011·Cell Research·Emmanuelle SzenkerGeneviève Almouzni
Jul 19, 2011·Biochimica Et Biophysica Acta·Qing LiZhiguo Zhang
Jan 24, 2012·Nature Reviews. Molecular Cell Biology·Eric J Wagner, Phillip B Carpenter
Jan 31, 2012·Nature Genetics·Gang WuUNKNOWN St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project
Apr 18, 2012·Genes & Development·Hanno Hock
May 10, 2012·The EMBO Journal·Akihito HaradaYasuyuki Ohkawa
Nov 13, 2012·Nature Structural & Molecular Biology·Chao-Pei LiuRui-Ming Xu

❮ Previous
Next ❯

Citations

Oct 28, 2019·Methods : a Companion to Methods in Enzymology·Mowei ZhouLjiljana Paša-Tolić

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Genetics & Development
Simon J ElsaesserC David Allis
The International Journal of Developmental Biology
Guillermo A OrsiBenjamin Loppin
Cell Research
Emmanuelle SzenkerGeneviève Almouzni
Cell and Tissue Research
Burcu Biterge, Robert Schneider
© 2021 Meta ULC. All rights reserved