Histones and histone modifications in perinuclear chromatin anchoring: from yeast to man

EMBO Reports
Jennifer C HarrSusan M Gasser

Abstract

It is striking that within a eukaryotic nucleus, the genome can assume specific spatiotemporal distributions that correlate with the cell's functional states. Cell identity itself is determined by distinct sets of genes that are expressed at a given time. On the level of the individual gene, there is a strong correlation between transcriptional activity and associated histone modifications. Histone modifications act by influencing the recruitment of non-histone proteins and by determining the level of chromatin compaction, transcription factor binding, and transcription elongation. Accumulating evidence also shows that the subnuclear position of a gene or domain correlates with its expression status. Thus, the question arises whether this spatial organization results from or determines a gene's chromatin status. Although the association of a promoter with the inner nuclear membrane (INM) is neither necessary nor sufficient for repression, the perinuclear sequestration of heterochromatin is nonetheless conserved from yeast to man. How does subnuclear localization influence gene expression? Recent work argues that the common denominator between genome organization and gene expression is the modification of histones and in some ca...Continue Reading

References

Feb 1, 2003·Science·Thierry CheutinTom Misteli
Mar 12, 2003·The EMBO Journal·Lakshmi AtchisonMichael L Atchison
Jun 14, 2003·TheScientificWorldJournal·Roland Foisner
May 18, 2004·Genes & Development·Gunnar SchottaThomas Jenuwein
Oct 29, 2004·The EMBO Journal·Jonathan BaxterAmanda G Fisher
Jan 29, 2005·The EMBO Journal·Joost H A MartensThomas Jenuwein
Mar 16, 2005·Developmental Biology·Fátima SantosWendy Dean
Dec 13, 2005·Journal of Cell Science·Andreas BrachnerJosef Gotzmann
Dec 24, 2005·Journal of Cell Science·Ruth R E WilliamsAmanda G Fisher
Jun 1, 2006·Molecular Reproduction and Development·Catherine MartinNathalie Beaujean
Aug 1, 2006·Nature Genetics·Helen PickersgillBas van Steensel
Feb 27, 2007·Trends in Cell Biology·Ayelet MargalitYosef Gruenbaum
May 17, 2007·Journal of Cell Science·Jenny Alfredsson-TimminsPernilla Bjerling
Jul 3, 2007·Nature·Tarjei S MikkelsenBradley E Bernstein
Mar 4, 2008·Nature Genetics·Mareike PuschendorfAntoine H F M Peters
Oct 22, 2008·Chromosoma·Jenny Alfredsson-TimminsPernilla Bjerling
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Barna D FodorThomas Jenuwein
Dec 5, 2009·Journal of Cellular Biochemistry·Frank WilkinsonMichael L Atchison
Dec 29, 2009·Nature Genetics·Guillaume J Filion, Bas van Steensel
Jan 22, 2010·Cellular and Molecular Life Sciences : CMLS·Poonam MalikEric C Schirmer
Mar 26, 2010·Nature·Nadine L VastenhouwAlexander F Schier
Apr 17, 2010·Genes & Development·Peter MeisterSusan M Gasser
May 11, 2010·Cold Spring Harbor Perspectives in Biology·Katherine L Wilson, Roland Foisner

❮ Previous
Next ❯

Citations

Mar 5, 2016·Current Opinion in Cell Biology·Irina SoloveiYana Feodorova
May 21, 2016·Frontiers in Genetics·Rafal CzapiewskiEric C Schirmer
Oct 4, 2016·Worm·Adriana Gonzalez-Sandoval, Susan M Gasser
Jun 18, 2016·Trends in Genetics : TIG·Adriana Gonzalez-Sandoval, Susan M Gasser
Jun 24, 2016·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yoshie TangeYasushi Hiraoka
Nov 11, 2016·PLoS Pathogens·Karl KuchlerNeeraj Chauhan
Dec 14, 2016·The FEBS Journal·Camille SamsonSophie Zinn-Justin
Mar 28, 2017·Genome Research·Harmen J G van de WerkenBoris Joffe
Jul 3, 2017·Journal of Cell Science·Nana NaetarRoland Foisner
Jan 3, 2018·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yasuhiro HiranoYasushi Hiraoka
Oct 19, 2017·Nature Reviews. Molecular Cell Biology·Caroline Uhler, G V Shivashankar
Jul 27, 2017·Journal of Cell Science·Luca SardoZachary A Klase
Jun 19, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Judit SymmankGeraldine Zimmer-Bensch
Aug 23, 2018·Molecular Biology of the Cell·Anne de Bruyn KopsChristine Guthrie
Dec 27, 2018·Molecular Biology of the Cell·Lysie ChampionUlrike Kutay
Jun 22, 2019·Nucleic Acids Research·Berta N VazquezLourdes Serrano
Nov 6, 2018·Epigenetics & Chromatin·Alexey V PindyurinYuri Y Shevelyov
Sep 27, 2019·The Journal of Biological Chemistry·Zeenat FarooqMohammad Altaf
Sep 13, 2017·Molecular Genetics and Genomics : MGG·Heeyoun Bunch
Apr 23, 2019·PLoS Genetics·Mareike MöllerEva H Stukenbrock
Aug 21, 2020·Molecular Reproduction and Development·Yu-Guo YuanChen Qian
Feb 6, 2020·Neurochemical Research·Camila YattahPatrizia Casaccia
Oct 18, 2016·Oncology Reports·Shuai-Yin ChenGuang-Cai Duan
Nov 18, 2018·Current Genetics·Alejandro Juárez-Reyes, Irene Castaño
Oct 23, 2019·Cells·Paola GallardoSilvia Salas-Pino
Jan 18, 2017·Epigenetics & Chromatin·Sara El KennaniJérôme Govin
Apr 25, 2018·Nature Reviews. Molecular Cell Biology·Melanie A Eckersley-MaslinWolf Reik
Apr 6, 2019·Frontiers in Cell and Developmental Biology·Rafael A FissoreKarin Lykke-Hartmann
Apr 4, 2020·Genome Biology·Nolwenn Briand, Philippe Collas
Nov 15, 2016·Oncology Reports·Jian-Wei WeiChun-Sheng Kang
Aug 1, 2018·Nature Plants·Ezgi Süheyla Doğan, Chang Liu
Dec 18, 2020·Nature Communications·Connor H O' MearaChristopher R Parish
Mar 25, 2021·Life Science Alliance·Xianrong WongKaren L Reddy
Mar 29, 2021·Current Opinion in Genetics & Development·Victoria E HoskinsKaren L Reddy
Dec 19, 2020·Current Opinion in Genetics & Development·Peter Askjaer, Jennifer C Harr

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Methods Mentioned

BETA
immunoprecipitation
acetylation
Y2H
environmental stress

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