PMID: 6412752Aug 16, 1983Paper

Histones of terminally differentiated cells undergo continuous turnover

Biochemistry
L DjondjurovE Ivanova

Abstract

In contrast to the widely accepted idea of the nearly absolute metabolic stability of histones, our experiments support the view that the histones of nonproliferating, terminally differentiated cells undergo continuous replacement. This conclusion is based on the incorporation of labeled amino acids into the histones of mouse kidney and liver cells after their intraperitoneal introduction. We have found that the intranuclear uptake of the histones made in the absence of replicative synthesis and their integration into chromatin proceed with striking delay. The metabolic rates of individual histones measured by calculating their half-lives suggest that each histone turns over at a specific rate. With regard to the basic chromatin structure, the nucleosome, such unequal turnover should mean that the histone core does not participate in this process as a single unit but rather as a protein mosaic in which each partner follows its own rate of removal. Additional experiments suggested that intact nucleosomes take part in the replacement, but the relative proportion of the nucleosomes involved should be limited. The nonnucleosomal H1A and H1 degree histones have been found to undergo faster replacement than the core histones. Moreove...Continue Reading

Citations

Jan 1, 1984·Journal of Molecular Evolution·J MezquitaG H Dixon
Jan 1, 1987·Developmental Biology·A M WunschJ Lough
Jun 12, 1990·Biochimica Et Biophysica Acta·R J Heads, B G Carpenter
Dec 7, 1987·Biochimica Et Biophysica Acta·D De Bellis, M I Horowitz
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·N YanchevaL Djondjurov
Nov 5, 2011·Journal of Proteome Research·Sidney B CambridgeMatthias Mann
Nov 27, 2009·The Journal of Biological Chemistry·Barry M ZeeBenjamin A Garcia
Aug 1, 1986·The Journal of Cell Biology·L H WuM Rechsteiner
Jan 1, 1986·CRC Critical Reviews in Biochemistry·R S WuW M Bonner
Apr 17, 2009·The Journal of Nutritional Biochemistry·Subhashinee S K WijeratneJanos Zempleni
Jun 18, 1985·Biochemistry·L Louters, R Chalkley
Jan 1, 1989·Experimental Cell Research·S TsvetkovL Djondjurov
May 1, 1992·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Philippe AlbertIsabelle Lacorre-Arescaldino
Dec 20, 2020·Analytical Biochemistry·Andrea Arias-AlvaradoTakhar Kasumov
Jun 1, 1985·Molecular and Cellular Biology·E SaribanW M Bonner
May 1, 1984·Experimental Cell Research·L P DjondjurovK Christov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.