PMID: 999143Nov 1, 1976Paper

Histopathologic and experimental models for sensory and neural deafness

The Annals of Otology, Rhinology, and Laryngology
G J Spector

Abstract

Six selected cases with neonatal and fetal cochlear pathology are presented. Those denoting cochlear sepsis are: H. influenza purulent labyrinthitis, cytomegalovirus endolabyrinthitis, and aseptic meningitis and labyrinthitis. Those denoting cochlear neural aplasia are Goldenhar's syndrome, left-sided cardiac hypoplasia with partial basal turn neural aplasia, and cerebral cortical and ventricular hemorrhage with modiolar extension. These findings are compared to the fluorocitrate ototoxicity model for neural deafness in the guinea pig. This study suggests hypotheses for viral trophism in the inner ear and neural degeneration of the cochlea as mechanisms for sensorineural deafness.

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Citations

Oct 1, 1985·Journal of Communication Disorders·P Belenchia, P McCardle
Oct 20, 2001·The Annals of Otology, Rhinology, and Laryngology·M MiuraB E Hirsch
Jul 1, 1986·The Annals of Otology, Rhinology, and Laryngology·I Sando, M Ikeda
Jul 13, 2001·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·A W ScholtzA Schrott-Fischer
Jul 1, 1984·The Annals of Otology, Rhinology & Laryngology. Supplement·G J Spector

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