Histopathologic and ultrastructural features and claudin expression in papillary tumors of the pineal region: a multicenter analysis

The American Journal of Surgical Pathology
Michelle Fèvre MontangeAnne Jouvet

Abstract

Neuroepithelial papillary tumor of the pineal region (PTPR) has been defined as a distinct entity that is increasingly being recognized, with 96 cases now reported. This tumor shares morphologic features with both ependymomas and choroid plexus tumors. PTPR is characterized by an epithelial-like growth pattern in which the vessels are covered by layers of tumor cells forming perivascular pseudorosettes. These tumors exhibit various combinations of papillary and solid architecture, making the differential diagnosis of PTPR difficult to establish. We report the detailed description of the histopathologic features of a large series of PTPRs from 20 different centers and distinguish 2 subgroups of tumors with either a striking papillary growth pattern or a papillary and solid growth pattern. We highlight the findings that PTPRs have unusual vessels with multiple lumina and frequently show detachment of the border of the tumoral cells from the vascular wall. The 2 PTPR subgroups present similar clinical characteristics and immunophenotypes. We confirmed and extended the results of previous ultrastructural studies on the presence of intercellular junctions at the apical part of tumoral cells. The expression of the tight junction prot...Continue Reading

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Citations

Feb 19, 2016·Asian Journal of Neurosurgery·Sushil Kumar AggarwalRabi Narayan Sahu
Oct 16, 2015·Journal of Pathology and Translational Medicine·Na Rae Kim, Sung-Hye Park
May 28, 2016·Acta Neuropathologica Communications·Maria-Magdalena GeorgescuJack M Raisanen
May 13, 2015·The Neuroradiology Journal·Asim F ChoudhriFrederick A Boop
Apr 17, 2019·Neurosurgery·Vitor Nagai YamakiEberval Gadelha Figueiredo
Jun 27, 2015·Brain Pathology·Stephanie HeimMartin Hasselblatt
Sep 15, 2020·Neurosurgery Clinics of North America·Saber Tadros, Abhik Ray-Chaudhury

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