PMID: 8951758Nov 1, 1996Paper

Histopathologic appearance of arterial occlusions with hydrogel and polyvinyl alcohol embolic material in domestic swine

Journal of Vascular and Interventional Radiology : JVIR
D P LinkM A Samphilipo

Abstract

This study observes the histologic changes resulting from a hydrogel embolic agent (polyacrylonitrile [PAN]) compared with polyvinyl alcohol particles (PVA) of similar size. Hepatic and renal embolizations were performed in 13 domestic swine by selecting small (1-mm) branches utilizing a coaxial 3-F microcatheter. The hydrogel embolic agent (tantalum-loaded and plain) and PVA were delivered through microcatheters. The longest follow-up period was 8 weeks. Postmortem examination of the embolized tissues included gross examination and histologic analysis. Tantalum-loaded PAN particles were radiopaque and seen in groups fluoroscopically and individually with specimen radiography. Histologic studies showed similar luminal and cellular response to PVA and the hydrogel embolic agents. The arterial lesion induced by the hydrogel embolic agents led to an absence of the arterial wall locally in the area of deployment. Hydrogel embolic particles became surrounded in fibrous connective tissue with no arterial wall. PVA and porous hydrogel capsules produced an inflammatory response, resulting in less wall reorganization, and surrounding fibrous connective tissue at 8 weeks than the solid PAN particles. These hydrogel embolic create a perma...Continue Reading

References

Apr 1, 1989·Journal of Microencapsulation·B C Thanoo, A Jayakrishnan

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Citations

May 8, 2001·Journal of Biomedical Materials Research·T NakamuraY Shimizu
Jan 25, 2008·Cardiovascular and Interventional Radiology·Sibylle StampflGoetz M Richter
Nov 17, 2009·Cardiovascular and Interventional Radiology·Cagin SenturkA Yigit Goktay
Nov 12, 2010·Cardiovascular and Interventional Radiology·Eleni Liapi, Jean-Francois H Geschwind
Apr 13, 2013·Cardiovascular and Interventional Radiology·Ruben Lopez-BenitezJoachim Kettenbach
Feb 13, 2002·American Journal of Surgery·D W EasterG Johnson
Dec 16, 2005·Investigative Radiology·Alexandre LaurentJean-Jacques Merland
Dec 24, 2004·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·C Michael GrossRainer Dietz
Aug 23, 2000·AJR. American Journal of Roentgenology·G P SiskinE G Dolen
Jan 15, 2003·Journal of Vascular and Interventional Radiology : JVIR·Gary P SiskinDavid Todd
Dec 5, 2006·Journal of Vascular and Interventional Radiology : JVIR·Akira YamamotoKeiji Umetani
Apr 27, 2019·Cardiovascular and Interventional Radiology·V VidalB Guillet
May 14, 2020·International Journal of Surgical Pathology·Cassandra Bruce-Brand, Jonathan Rigby
Feb 1, 2018·Journal of Maxillofacial and Oral Surgery·S C Nair

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