Histopathologic Changes of the Inner ear in Rhesus Monkeys After Intratympanic Gentamicin Injection and Vestibular Prosthesis Electrode Array Implantation

Journal of the Association for Research in Otolaryngology : JARO
Daniel Q SunCharles C Della Santina

Abstract

Bilateral vestibular deficiency (BVD) due to gentamicin ototoxicity can significantly impact quality of life and result in large socioeconomic burdens. Restoring sensation of head rotation using an implantable multichannel vestibular prosthesis (MVP) is a promising treatment approach that has been tested in animals and humans. However, uncertainty remains regarding the histopathologic effects of gentamicin ototoxicity alone or in combination with electrode implantation. Understanding these histological changes is important because selective MVP-driven stimulation of semicircular canals (SCCs) depends on persistence of primary afferent innervation in each SCC crista despite both the primary cause of BVD (e.g., ototoxic injury) and surgical trauma associated with MVP implantation. Retraction of primary afferents out of the cristae and back toward Scarpa's ganglion would render spatially selective stimulation difficult to achieve and could limit utility of an MVP that relies on electrodes implanted in the lumen of each ampulla. We investigated histopathologic changes of the inner ear associated with intratympanic gentamicin (ITG) injection and/or MVP electrode array implantation in 11 temporal bones from six rhesus macaque monkeys...Continue Reading

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Citations

May 27, 2016·Journal of Neurophysiology·Richard D RabbittRebecca Lim
May 15, 2018·Journal of Neural Engineering·Robert K ShepherdDavid A X Nayagam
Jun 27, 2017·Ear and Hearing·Ruth Van HeckeLeen Maes
Nov 15, 2019·JCI Insight·Peter J BoutrosCharles C Della Santina
Mar 15, 2018·Frontiers in Neuroscience·Lejo Johnson ChackoAnneliese Schrott-Fischer
Mar 24, 2018·Current Otorhinolaryngology Reports·Desi P SchooJohn P Carey
Jun 6, 2019·Journal of the Association for Research in Otolaryngology : JARO·Abderrahmane HedjoudjeCharles C Della Santina
Jul 26, 2018·Frontiers in Neurology·Ruben HermannCaroline Tilikete
Jul 12, 2020·Journal of Vestibular Research : Equilibrium & Orientation·Raymond van de BergNils Guinand

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