Histopathologic characteristics of background parenchymal enhancement (BPE) on breast MRI

Breast Cancer Research and Treatment
Janice S SungMalcolm C Pike

Abstract

Breast fibroglandular tissue (FGT), as visualized on a mammogram (mammographic density, MD), is one of the strongest known risk factors for breast cancer. FGT is also visible on breast MRI, and increased background parenchymal enhancement (BPE) in the FGT has been identified as potentially a major breast cancer risk factor. The aim of this exploratory study was to examine the biologic basis of BPE. We examined the unaffected contra-lateral breast of 80 breast cancer patients undergoing a prophylactic mastectomy before any treatment other than surgery of their breast cancer. BPE was classified on the BI-RADS scale (minimal/mild/moderate/marked). Slides were stained for microvessel density (MVD), CD34 (another measure of endothelial density), glandular tissue within the FGT and VEGF. Spearman correlations were used to evaluate the associations between BPE and these pathologic variables. In pre-menopausal patients, BPE was highly correlated with MVD, CD34 and glandular concentration within the FGT, and the pathologic variables were themselves highly correlated. The expression of VEGF was effectively confined to terminal duct lobular unit (TDLU) epithelium. The same relationships of the four pathologic variables with BPE were seen ...Continue Reading

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Citations

Mar 8, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christiane K Kuhl
Apr 21, 2019·Journal of Magnetic Resonance Imaging : JMRI·Geraldine J LiaoHabib Rahbar
Aug 18, 2020·Journal of Breast Imaging·Vignesh A ArasuUNKNOWN ISPY2 investigators
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Sep 3, 2020·AJR. American Journal of Roentgenology·Bethany L NiellYoganand Balagurunathan
Jul 27, 2021·Clinical Imaging·Saish NeppalliDonna B Taylor
Jan 12, 2022·Breast Cancer Research and Treatment·Carolyn L WesthoffRichard Ha

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