Histopathologic Features of Colorectal Adenoma and Adenocarcinoma Developing Within Inflammatory Polyps in Miniature Dachshunds

Veterinary Pathology
Tsubasa SaitoHiroyuki Nakayama

Abstract

Biopsy samples of colorectal polyps were collected and examined from 67 Miniature Dachshund dogs (including 35 cases with an additional biopsy). Histopathologic diagnoses of the initial biopsy samples were "inflammatory polyp" in 52 cases (78%), "adenoma" in 10 cases (15%), and "adenocarcinoma" in 5 cases (8%). Eight of 10 cases (80%) diagnosed as adenoma also had inflammatory polyp lesions in the same specimen. A second biopsy was performed in 25 cases (48%) initially diagnosed with inflammatory polyp. Pathologic diagnoses for the second biopsy were inflammatory polyp in 11 cases (44%), adenoma in 9 cases (36%), and adenocarcinoma in 5 cases (20%). The number of beta-catenin-positive nuclei in epithelial cells was significantly higher in adenoma (46%) and adenocarcinoma (75%) as compared with inflammatory polyp (6%). Normal epithelial cells and hyperplastic goblet cells in inflammatory polyps showed homogeneous positive cytoplasmic immunoreactivity for adenomatous polyposis coli (APC) antigen. However, APC expression was decreased in areas of intense nuclear beta-catenin expression in adenoma and adenocarcinoma lesions. Foci of cytokeratin 5/6-positive squamous cell-like neoplastic cells showed intense beta-catenin nuclear exp...Continue Reading

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Citations

Nov 30, 2019·Surgical Case Reports·Takayuki OkunoSoichiro Ishihara
May 20, 2020·Journal of Toxicologic Pathology·Tsubasa SaitoHiroyuki Nakayama
Nov 20, 2020·Veterinary Pathology·Mizuho UneyamaHiroyuki Nakayama
Dec 18, 2020·The Journal of Veterinary Medical Science·Aki OhmiHajime Tsujimoto

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Methods Mentioned

BETA
biopsy
biopsies
nuclear translocation

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