PMID: 2496220Jan 1, 1989Paper

Histopathologic features of DMBA-induced mammary tumors in blind-underfed, blind-anosmic, and blind cold-exposed rats: influence of the pineal gland

Journal of Pineal Research
S CosE J Sánchez-Barceló

Abstract

The influence of the pineal gland on the histopathologic changes induced in mammary glands by 7, 12-dimethylbenz(a)-anthracene (DMBA) has been studied. To achieve the maximum expression of pineal action in animals, 28-day-old female Sprague-Dawley rats were subjected to one of the following treatments: blindness + olfactory bulbectomy (BA), blindness + underfeeding (BU), or blindness + cold exposure (BC). Half of the rats in each group were also pinealectomized. Animals that were intact or only pinealectomized served as controls. Each animal received a single intragastrical dose of DMBA (20 mg) 4 weeks after performing the treatments mentioned above. At 28 weeks of age animals were sacrificed, and mammary tumors as well as mammary glands without macroscopic lesions were collected. Animals of the BU group failed to develop any tumors throughout the 20-week control period. In the remaining groups, tumors were found; the relation between number of adenocarcinomas (AC) and fibroadenomas was similar, always with a greater incidence of ACs. Some ACs showed areas with changes in the ductal epithelium that are considered signs of tumoral regression; pinealectomized animals had the lowest incidence of ACs with signs of regression. Ductu...Continue Reading

References

Jan 1, 1979·Oncology·V M DilmanM A Azarova
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S Z Haslam, H A Bern
Jan 1, 1979·Neuroendocrinology·D E Blask, J L Nodelman
Feb 15, 1977·Experientia·J Kuszak, M Rodin
Feb 1, 1986·Cryobiology·E J Sánchez-BarcelóM D Mediavilla
Sep 1, 1974·Journal of the National Cancer Institute·D Sinha, T L Dao
Oct 1, 1969·The British Journal of Surgery·T Hamilton
Aug 1, 1969·Journal of Reproduction and Fertility·R J ReiterR J Donofrio
Mar 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·D C Herbert, R J Reiter
Jan 1, 1959·The Journal of Experimental Medicine·C HUGGINSH SUTTON
Apr 1, 1963·The Journal of Pathology and Bacteriology·S YOUNGL E SUTHERLAND
Jan 1, 1964·Progress in Experimental Tumor Research·T L DAO

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Citations

Aug 1, 1992·Journal of Pineal Research·M D MediavillaE J Sánchez-Barceló
Aug 5, 2005·International Journal of Cancer. Journal International Du Cancer·Samuel CosEmilio J Sánchez-Barceló
Apr 15, 2000·Frontiers in Neuroendocrinology·S Cos, E J Sánchez-Barceló
May 4, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A G RatoS Ramos
Feb 24, 2005·Molecular and Cellular Biochemistry·M C SaezE Ortega

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