Histopathologic features of the tumor budding in adenocarcinoma of the lung: tumor budding as an index to predict the potential aggressiveness

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Yoko YamaguchiA Ochiai

Abstract

The term tumor budding has been applied to single cells or small clusters of up to four cells within the stromal tissue at the invasive margin of colorectal cancers. This morphologic feature is increasingly being recognized as an adverse prognostic factor. The purpose of this study was to evaluate the clinicopathologic significance of tumor budding in adenocarcinomas of the lung. We investigated the relationship between tumor budding and clinicopathologic parameters of adenocarcinomas of the lung and the prognostic significance of tumor budding by reviewing the cases of 201 consecutive patients who had undergone complete resection of adenocarcinoma of the lung measuring 30 mm or less in diameter. We examined immunohistochemical profile of budding cells (BCs) by immunohistochemical staining with 14 antibodies. Tumor budding was observed in 78 (43.1%) of the 181 cases with invasive adenocarcinoma. The presence of tumor budding was significantly associated with lymph node metastasis (p = 0.005), pathologic stage (p < 0.001), vascular invasion (p = 0.003), lymphatic invasion (p = 0.009), and pleural invasion (p = 0.029). Examination of the relation between the presence of tumor budding and the predominant histologic subtype reveale...Continue Reading

References

Jan 1, 1995·Diseases of the Colon and Rectum·K HaseM Trollope
Jul 1, 1993·Diseases of the Colon and Rectum·K HaseM Vierra
May 7, 1998·The International Journal of Biochemistry & Cell Biology·C D Bingle
May 23, 2002·The American Journal of Surgical Pathology·Yasushi YatabeTakashi Takahashi
Dec 25, 2002·European Journal of Radiology·C J Beadsmoore, N J Screaton
Dec 28, 2002·The American Journal of Surgical Pathology·Tatsu MiyoshiYuichi Ishikawa
Oct 20, 2004·Annals of Surgery·Hideki UenoIan C Talbot
Feb 18, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Akiko Miyagi MaeshimaYoshihiro Matsuno
Jan 6, 2007·Histopathology·F Prall
Mar 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Takehito KawakamiHiroshi Iwasaki
Feb 28, 2009·The International Journal of Developmental Biology·M Angela Nieto
Jun 2, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tatsuya NaganoAtsushi Ochiai

❮ Previous
Next ❯

Citations

Jun 7, 2012·Annals of Surgical Oncology·Teruhisa TakuwaAtsushi Ochiai
Dec 14, 2012·World Journal of Gastroenterology : WJG·Fabio GrizziLuigi Laghi
Sep 4, 2012·Molecular Medicine Reports·Ryota MasudaMasayuki Iwazaki
Jun 20, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kyuichi KadotaWilliam D Travis
Dec 18, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jan H von der ThüsenAndrew G Nicholson
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN WHO Panel
Aug 19, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yusuke TakahashiAtsushi Ochiai
Jul 18, 2015·Histopathology·Alhadi AlmangushIlmo Leivo
Nov 27, 2015·Pathology, Research and Practice·Duygu GürelSülen Sarıoğlu
Oct 20, 2015·Human Pathology·Viktor H KoelzerAlessandro Lugli
Apr 13, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Cheng WangXiqiang Liu
Oct 8, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kaori KogaKazuki Nabeshima
Dec 14, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tetsuhiko TairaAtsushi Ochiai
Jan 27, 2015·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·B V ManjulaA Mathan Mohan
May 3, 2016·Journal of Clinical Medicine·Alexandru Dan GrigoreHerbert Levine
Mar 2, 2017·The American Journal of Surgical Pathology·Kyuichi KadotaReiji Haba
May 15, 2018·British Journal of Cancer·Philipp LohneisAnja Jühling
Mar 31, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Nan XieCheng Wang
Dec 1, 2017·British Journal of Cancer·Alhadi AlmangushIlmo Leivo
Dec 5, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christina NepplSabina Berezowska
Sep 10, 2020·Nature Reviews. Clinical Oncology·Alessandro LugliIris D Nagtegaal
Apr 26, 2015·International Journal of Surgical Pathology·Mine GulluogluEmre Balik
Apr 22, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mariyo Rokutan-KurataHironori Haga
Nov 2, 2017·Journal of Cancer Research and Clinical Oncology·Yukiko MatsuoYukitoshi Satoh
Oct 31, 2019·World Journal of Gastrointestinal Oncology·Yi-Xian GuoEn-Hao Zhao
Feb 8, 2020·Indian Journal of Pathology & Microbiology·Shaymaa A SadekSohaila Fatima
Nov 3, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Tu Van DaoThuan Van Tran
Nov 11, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Lanqing CaoLijuan Wei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.