PMID: 8599449Oct 1, 1995Paper

Histopathologic findings in the clinically uninvolved skin of patients with mycosis fungoides

The American Journal of Dermatopathology
R BergmanR Friedman-Birnbaum

Abstract

Several of the methods of treating plaque-stage mycosis fungoides (MF) advocate treatment of the whole skin, although relatively little information exists on the histologic appearance of clinically uninvolved MF skin. Our study was performed to elucidate the histologic appearance of the clinically uninvolved skin of plaque-stage MF patients. Biopsies were taken from the clinically uninvolved skin of 18 untreated patients with plaque-stage MF, 1 cm (near) and > or = 10 cm (far) from the MF plaques, and from 23 normal, healthy controls. Eight to 12 serial sections from each specimen were examined. The most common histologic finding, which was observed in six (33%) biopsies of near skin and four (22%) biopsies of far skin compared with only one (4%) biopsy of normal control (p = 0.02 and 0.1, respectively), consisted of mononuclear-cell infiltrate around a blood vessel in the papillary dermis, with extension of some of these cells into the overlying epidermis. More diffuse and epidermotropic mononuclear cell infiltrates were seen in an additional three (17%) biopsies of near skin, whereas mild nonepidermotropic superficial perivascular or perifollicular mononuclear cell infiltrates were observed in an additional four (17%) biopsie...Continue Reading

Citations

Sep 7, 2000·Ceskoslovenská patologie·F FakanS Námĕstek
May 20, 2015·Journal of the American Academy of Dermatology·Aurélia HennEve Maubec
Dec 1, 2012·Anais Brasileiros De Dermatologia·Thamy YamashitaSilvio Alencar Marques
Sep 12, 2006·International Journal of Dermatology·Mohammad A El-DaroutiMona R E Abdel-Halim
Feb 26, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·R FriedlandE Hodak

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