Histopathologic, immunohistochemical, and cytologic analysis of feline myeloma-related disorders: further evidence for primary extramedullary development in the cat

Veterinary Pathology
P J MellorM J Day

Abstract

Feline myeloma-related disorders (MRD) are rare neoplasms of plasma cells. The multistep transformation model of myeloma in humans is based on the premise that plasma cells undergo neoplastic transformation primarily within the intramedullary compartment and that over time they become poorly differentiated and metastasize to extramedullary locations. Historically, diagnostic criteria used for human multiple myeloma have been applied to the cat, with the assumption that feline MRD commonly arises in the intramedullary compartment. Our objectives were to describe the features of feline MRD confirmed by cytology, histopathology, histochemistry, and immunohistochemistry and to categorize these tumors. A priori hypotheses were 1) tumor category predicts survival and 2) cats with well-differentiated tumors commonly have extramedullary involvement in contrast to human myeloma patients. This multicenter, retrospective study identified 26 MRD cases. There was good agreement between histopathologic and cytologic tumor categorization. Histochemistry and immunohistochemistry were shown to be valuable adjunct tests in the diagnosis of MRD. Cats with well-differentiated tumors had increased median survival relative to those with poorly diffe...Continue Reading

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Citations

Jan 21, 2012·Veterinary Immunology and Immunopathology·Hiroyuki MochizukiHajime Tsujimoto
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Jun 28, 2011·Veterinary Immunology and Immunopathology·Hiroyuki MochizukiHajime Tsujimoto
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Mar 23, 2018·Journal of Veterinary Internal Medicine·Ricardo Fernández, Esther Chon
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Jul 5, 2019·Veterinary Clinical Pathology·A Russell Moore, Paul R Avery
Apr 20, 2021·JFMS Open Reports·Oliver MarshFabio Stabile

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Methods Mentioned

BETA
biopsy
biopsies
electrophoresis
bone marrow aspiration

Software Mentioned

XLSTAT
SPSS

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