Histopathologic parameters as predictors of response to endoscopic sinus surgery in nonallergic patients with chronic rhinosinusitis

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Tomislav BaudoinLivije Kalogjera

Abstract

To estimate the predictable value of histopathologic parameters in chronic rhinosinusitis (CRS) for response to endoscopic sinus surgery (ESS). Symptomatology was rated in 100 patients prior to as well as 12 and 24 months after surgery. Specimens taken during the procedure were examined and scored for goblet cells, subepithelial thickening, mast cells, and eosinophils. Multiple regression analysis was performed to predict the total score of subjective symptoms before treatment by histopathologic parameters. The correlation between histopathologic parameters and postoperative symptoms was then evaluated. Goblet cells were the best predictor correlating with 5 symptoms. Subepithelial thickening correlated with 4 symptoms. Mast cell infiltration correlated with 3 symptoms. Eosinophilic infiltration correlated with only one symptom (P<0.05). Certain histopathologic parameters in CRS are predictive of favorable response to ESS. Pathologic evaluation may help the ENT surgeon to predict the persistence of certain CRS symptoms after ESS, even in patients at low risk for surgical failure. C-4.

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Citations

Jan 16, 2014·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Mohammad NaeimiMohammad Reza Naeimi
Apr 28, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Mojtaba Mohammadi ArdehaliMandana Amiri
Sep 30, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Zachary M SolerTimothy L Smith
Nov 16, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Tomislav BaudoinMirjana Kujundzić Tiljak
Jan 13, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Boris JelavicTomislav Baudoin
Jun 7, 2013·International Forum of Allergy & Rhinology·Fatih Kemal SoySemih Oncel
Jan 31, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Marko Velimir GrgićTomislav Baudoin
Dec 3, 2014·American Journal of Otolaryngology·C AdnaneM Mahtar
Mar 8, 2013·International Forum of Allergy & Rhinology·Edward John ClelandPeter-John Wormald
Mar 16, 2012·International Forum of Allergy & Rhinology·Kornkiat SnidvongsRichard J Harvey
Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Woo-Jin JeongChae-Seo Rhee
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Dec 12, 2018·Scientific Reports·Yu SongQingkun Song
Dec 18, 2014·World Journal of Clinical Cases·En-Tong WangLi-Juan Guo
Jan 11, 2007·Current Opinion in Otolaryngology & Head and Neck Surgery

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Methods Mentioned

BETA
biopsy
lavage

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