Histopathological analysis of Salmonella chronic carriage in the mouse hepatopancreatobiliary system

PloS One
Geoffrey Gonzalez-EscobedoJohn S Gunn

Abstract

Salmonella Typhi asymptomatic chronic carriage represents a challenge for the diagnosis and prevention of typhoid fever in endemic areas. Such carriers are thought to be reservoirs for further spread of the disease. Gallbladder carriage has been demonstrated to be mediated by biofilm formation on gallstones and by intracellular persistence in the gallbladder epithelium of mice. In addition, both gallstones and chronic carriage have been associated with chronic inflammation and the development of gallbladder carcinoma. However, the pathogenic relationship between typhoid carriage and the development of pre-malignant and/or malignant lesions in the hepatopancreatobiliary system as well as the host-pathogen interactions occurring during chronic carriage remains unclear. In this study, we monitored the histopathological features of chronic carriage up to 1 year post-infection. Chronic cholecystitis and hepatitis ranging from mild to severe were present in infected mice regardless of the presence of gallstones. Biliary epithelial hyperplasia was observed more commonly in the gallbladder of mice with gallstones (uninfected or infected). However, pre-malignant lesions, atypical hyperplasia and metaplasia of the gallbladder and exocrin...Continue Reading

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Jul 9, 2014·Current Opinion in Gastroenterology·Jason C Hall, Howard C Crawford
Jul 30, 2014·Trends in Microbiology·John S GunnEdward T Ryan
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Jul 21, 2021·Journal of Korean Medical Science·Seong Ji ChoiDongho Choi

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