PMID: 3213508May 1, 1988Paper

Histopathological analysis of surgically resected myocardium in patients with sustained ventricular tachycardia

Acta Pathologica Japonica
C YutaniT Ohe

Abstract

Surgical resection of the endocardium and subendocardium often abolishes sustained ventricular tachycardia (VT) in patients with old myocarcial infarct (OMI), unknown myocardial disease, and arrhythmogenic right ventricular dysplasia (ARVD), presumably by interrupting the reentrant pathway. In order to define the morphologic characteristics of histologic components in the reentrant pathway, we carried out histopathological analysis of surgically resected specimens from 17 patients who underwent this procedure. Bundles of apparently viable and hydropic myocardial fibers embedded in dense fibrous and adipose tissues were identified throughout the specimens obtained from OMI, ARVD and idiopathic VT cases. In 3 patients with idiopathic VT, most of the resected areas were composed of ventricular muscle, the components of which appeared histologically similar to Purkinje fibres. In all patients, the abnormal muscle cells were characterized by a loss of contractile elements, hydropic cytoplasm and an elliptic shape. Such an abnormal structure and arrangement of surviving cardiac fibers following tissue injury might play an important role in creating abnormalities of transmembrane potential, leading to the micro-reentrant circuits that...Continue Reading

References

Nov 1, 1985·The Journal of Thoracic and Cardiovascular Surgery·D A OttD G McNamara
Sep 1, 1985·Acta Pathologica Japonica·C YutaniY Aragaki
Nov 1, 1984·Journal of the American College of Cardiology·D D SugrueS C Hammill
Jan 1, 1984·Annals of Internal Medicine·J S HochmanB H Bulkley
Feb 1, 1982·The American Journal of Cardiology·G FontaineY Grosgogeat
Feb 1, 1982·Circulation·F I MarcusY Grosgogeat
Aug 1, 1981·British Heart Journal·W J McKennaJ F Goodwin

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