Histopathological and biochemical effects of green tea and/or licorice aqueous extracts on thyroid functions in male albino rats intoxicated with dimethylnitrosamine.

Nutrition & Metabolism
A Abd El MgeedM Abdel Gabbar

Abstract

To investigate histopathological and biochemical effects of green tea and/or licorice aqueous extracts in thyroid functions in male albino rats intoxicated with Dimethylnitrosamine. 40 Male albino rats were divided into two main groups, 20 normal rats and 20 DMN intoxicated rats. Normal rats were subgrouped into 4 equal groups, group A without treatment (controls), group B treated with green tea, group C treated with licorice, group D treated with green tea and licorice. DMN intoxicated rats were subgrouped into 4 equal groups, group E treated with DMN, group F treated with DMN and green tea, group G treated with DMN and licorice, group H treated with DMN, green tea and licorice. The rats were permitted for free access to solubilized extracts of green tea and or licorice for 4 weeks. All rats in groups E, F, G, H were treated by intraperitoneal DMN (4 mg dissolved in 2.5 ml distilled water/kg body weight) seven times every 2 days in the first two weeks. Plasma total triiodothyronine and tetraiodothyronine were determined by radioimmunoassay. Thyroxine 5-monodeiodinase activity of liver was determined by spectrophotometeric method. Plasma thyroid stimulating hormone was determined by chemiluminometric technique. Histopathologica...Continue Reading

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Citations

Feb 20, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Khaled TaïbiKhalida Hadji

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