Histopathological and Biochemical Effects of Ecballium elaterium on Sepsis-Induced Lung Injury

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Melike DemirCengizhan Sezgi

Abstract

The aim of this study was to investigate the role of Ecballium elaterium (EE) on sepsis-induced lung injury. A total of 30 male rats were divided into three groups as follows: control, sepsis, and treatment groups (sepsis + EE) with each group containing 10 rats. A rat model of sepsis induced by cecal ligation and puncture (CLP) was used. In the treatment group, rats were injected intraperitoneally with 2.5 mg/kg EE after CLP. Interleukin-6 (IL-6), tumor necrosis factor (TNF)-α, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values after a 24-hr period were measured via cardiac puncture. Animals were harvested after the procedure and biochemical analysis was done and histopathological changes of the tissue sections of lungs were examined thereafter. A statistically significant decrease was observed in the IL-6 (p < .05), TNF-α (p < .05), and TOS (p < .01) levels in the sera of the treatment group compared to those of the sepsis group. Following the treatment, the TOS (p = .01) and OSI (p < .05) levels in the lung tissue of rats indicated a statistically significant decrease compared to those of the sepsis group. The histopathological follow-up undertaken after the administration of ...Continue Reading

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Citations

May 19, 2016·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Mehmet Serif ArslanSelcuk Otcu
Apr 14, 2017·Acta Cirúrgica Brasileira·Ítalo Medeiros AzevedoAldo Cunha Medeiros
Jun 20, 2020·Brazilian Dental Journal·Gabriela Veloso Vieira da Silva PinheiroMarcela Claudino

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