Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression

The Journal of Pathology. Clinical Research
Shingo InagumaMarkku Miettinen

Abstract

Aberrant PD-L1 (CD274) expression has been described in different types of tumour and linked to tumour aggressiveness and a poor prognosis. In primary colorectal carcinomas (CRCs), CD274 expression was reported to be associated with mismatch repair (MMR)-deficiency, BRAF mutation, and "stem-like" immunophenotype defined by down-regulation of homeobox protein CDX2 and membranous expression of activated leukocyte cell adhesion molecule (ALCAM). However, the immunophenotype and genotype of CD274-positive metastatic CRC have not been extensively analysed. In this study, 189 CRC metastases were evaluated immunohistochemically for CD274, MMR proteins, CDX2, and ALCAM expression. Immunostaining for CD4, CD8, and FOXP3 was also performed to characterize tumour-associated immune cells. In addition, 34 arbitrarily selected lesions were genotyped using Sanger- and next-generation sequencing. Univariate analyses showed no clear association between CD274 expression and clinicopathological parameters including MMR-deficiency or "stem-like" immunophenotype after adjustment for multiple testing. Comparison of the clinicopathological profiles of CD274-positive primary and metastatic tumours revealed in the latter younger age of occurrence (60.9...Continue Reading

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Citations

Jun 2, 2018·Journal of Immunology Research·Haiyan TaiCongjian Xu
Oct 5, 2018·BMC Cancer·Ramón Cantero-CidEduardo López-Collazo
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Feb 28, 2021·Virchows Archiv : an International Journal of Pathology·Aya Nagano-MatsuoSatoru Takahashi
Jul 25, 2021·International Journal of Molecular Sciences·Kenta KachiSatoru Takahashi

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Methods Mentioned

BETA
PCR
FACS

Clinical Trials Mentioned

NCT02060188
NCT02437071

Software Mentioned

EZR
FlowJo
ImageJ

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