Histopathological and immunocytochemical studies of Trypanosoma musculi infection of mice.

Infection and Immunity
K HirokawaJ W Albright

Abstract

Mice infected with Trypanosoma musculi developed hyperplasia of the spleen, lymph nodes, and liver; in contrast, their thymuses displayed transient involution. All organs returned to normal in a month or less. There was modest anemia, lasting until the parasites were cleared from the bloodstream, followed by a rapid influx of erythrocytes into the blood and a subsequent return to normal erythrocyte numbers. During the first 2 weeks, trypanosomes and trypanosome-derived substances were found in the livers and, in moderate amounts, in the red pulp of the spleens; thereafter, trypanosomes and trypanosome-derived substances gradually decreased in these organs. The lymphoreticular hyperplasia involved a large increase of immunoglobulin G (IgG)-containing cells in the spleens and lymph nodes at 2 weeks of infection. Hyperplasia of immunoglobulin-producing cells correlated with elevation of serum immunoglobulins, especially IgG. Cells producing IgG in the spleens proliferated mainly around the central arterioles of the white pulp, i.e., in the T-cell-dependent areas. The decline of trypanosome-derived substances in the livers and spleens was associated with marked hyperplasia of IgG-containing cells in the spleens and lymph nodes. The...Continue Reading

References

Mar 1, 1979·European Journal of Immunology·T W PearsonK S Mayor-Withey
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J W AlbrightD G Dusanic
Jan 1, 1979·Advances in Immunology·G F Mitchell
Jan 1, 1973·Transactions of the Royal Society of Tropical Medicine and Hygiene·K M Hudson, C Byner

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Citations

Mar 1, 1986·Parasite Immunology·A Ferrante
Oct 2, 2013·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Mandeep Singh BalP D Juyal
Jan 5, 2021·Current Zoology·Austin L NashDaniel T Blumstein
Feb 17, 1999·Experimental Parasitology·J W AlbrightJ F Albright
May 1, 1984·Infection and Immunity·J W AlbrightJ F Albright

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