PMID: 9442814Jan 27, 1998Paper

Histopathological and immunohistochemical features of the labial salivary glands in children with type I diabetes

Journal of Diabetes and Its Complications
A K Markopoulos, M Belazi

Abstract

The aim of this study was to investigate the morphological alterations of labial salivary glands in children with type I diabetes. For this purpose labial salivary glands under local anesthesia were excised from the lower lip of ten diabetic children at the onset of diabetes (mean age, 10 years). Additionally ten similar biopsies were obtained from ten healthy children (mean age, 9 years). The tissues were conventionally processed and embedded in paraffin wax. The first section was stained with hematoxylin/eosin, while two additional sections were stained immunohistochemically using the indirect immunoperoxidase avidin-biotin method to detect T and B lymphocytes. The results showed that a mononuclear infiltration was apparent in all diabetic children. Lymphocytes were particularly seen around various ducts. In contrast, the salivary glands of healthy controls were free of infiltrates. The immunohistochemical analysis showed that the majority of these cells were T cells. B cells were found to a lesser extent. These findings indicate that a destruction of labial salivary glands takes place in type I diabetes. This phenomenon is T-cell mediated. The similarity of this condition with the insulitis suggests that labial salivary glan...Continue Reading

References

Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·J MiyagawaS Tarui

❮ Previous
Next ❯

Citations

Mar 4, 1998·Diabetes Research and Clinical Practice·A K MarkopoulosD Drakoulakos
May 23, 2014·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·M VermaA Soni
Mar 14, 2013·Diabetes & Metabolic Syndrome·Masoumeh ShirzaiyJavid Dehghan
Jul 2, 2011·Oral Diseases·M IsolaM Cossu
May 12, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Monica PirasMarco Piludu
Oct 31, 2012·Archives of Oral Biology·Ana Luyza Domingues da Silva FariaEduardo José Caldeira
Jun 15, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·L IughettiS Bernasconi
Nov 29, 2016·Medicine·Barbara MalickaUrszula Kaczmarek
Aug 4, 1999·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A M PedersenB Nauntofte
Mar 23, 2017·Biochemistry Research International·Loai Aljerf, Iyad Alhaffar
Jan 13, 2021·Oral Diseases·Martin Haupt-JorgensenAnne Marie Lynge Pedersen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

The Journal of Experimental Biology
Hans HoppelerO Claire Moulton
Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Parviz M Pour
Archives of Oral Biology
Maija I MednieksR G Esquire
© 2021 Meta ULC. All rights reserved