Abstract
Use of the immune checkpoint inhibitor ipilimumab is sometimes complicated by ipilimumab-associated colitis (Ipi-AC), an immune-mediated colitis that mimics inflammatory bowel disease. We sought to characterize the histopathologic and immunophenotypic features of Ipi-AC and to directly compare these features to ulcerative colitis (UC). This is a retrospective cohort study of 22 patients with Ipi-AC, 12 patients with treatment-naïve UC and five controls with diarrhoea but normal endoscopic findings. Immunohistopathologic features were described, and quantitative immunohistochemistry (IHC) was performed for CD4, CD8, CD20, CD138 and FOXP3. Endoscopic findings in both the Ipi-AC and UC groups included ulcerated, oedematous and erythematous mucosa. Involvement of the GI tract was more diffuse in Ipi-AC. As compared to UC, a smaller proportion of Ipi-AC biopsies had basal plasmacytosis (14% for Ipi-AC vs. 92% for UC, P < 0.0001) and crypt distortion (23% for Ipi-AC vs. 75% for UC, P = 0.003), whereas Ipi-AC biopsies had more apoptotic bodies in the left colon (17.6 ± 15.3 for Ipi-AC vs. 8.2 ± 4.2 for UC, P = 0.011). Cryptitis, ulcerations and crypt abscesses were common in both groups. Biopsy specimens from Ipi-AC had a lower densit...Continue Reading
References
Jun 1, 1983·Gut·B B ScottD Jenkins
Jul 19, 2000·The Journal of Experimental Medicine·T TakahashiS Sakaguchi
Mar 13, 2001·Annual Review of Immunology·C A ChambersJ P Allison
Jun 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Giao Q PhanSteven A Rosenberg
Dec 23, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kristin SandersonJeffrey Weber
Nov 12, 2005·Annals of Surgical Oncology·Ajay V MakerSteven A Rosenberg
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ajay V MakerSteven A Rosenberg
Apr 15, 2006·Cancer·James M ReubenLuis H Camacho
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kimberly E BeckJames C Yang
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon ReadFiona Powrie
Dec 1, 2007·Journal of Immunotherapy·James C YangSteven A Rosenberg
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·F Stephen HodiGlenn Dranoff
Jun 12, 2008·The American Journal of Surgical Pathology·Darryl A ObleGregory Y Lauwers
Sep 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chrysoula I LiakouPadmanee Sharma
Jun 10, 2009·Digestive Diseases and Sciences·James D LordGeorge B McDonald
Jun 23, 2009·Cancer Biotherapy & Radiopharmaceuticals·David R MinorMohammed Kashani-Sabet
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Apr 17, 2012·Gastroenterology·William J SandbornStephen B Hanauer
May 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S WeberAxel Hauschild
May 2, 2013·Journal of Clinical Gastroenterology·Kisha A MitchellDouglas J Hartman
Jul 31, 2013·The Journal of Experimental Medicine·Tyler R SimpsonSergio A Quezada
Apr 30, 2014·Cancer Immunology Research·Mark J SelbyAlan J Korman
Apr 22, 2015·The New England Journal of Medicine·Caroline RobertUNKNOWN KEYNOTE-006 investigators
Apr 22, 2015·World Journal of Gastroenterology : WJG·Pawan RastogiMark C Mattar
Jun 2, 2015·The New England Journal of Medicine·Dung T LeLuis A Diaz
Jan 10, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Eduard Cornelis VerschurenNanne Klaas de Boer
Jan 15, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M MichotO Lambotte
Jan 24, 2016·Gut·Elizabeth D ThompsonRonan J Kelly
Oct 21, 2016·Oncoimmunology·Edurne ArriolaChristian Ottensmeier
Nov 3, 2016·The New England Journal of Medicine·Douglas B JohnsonJavid J Moslehi
Apr 5, 2017·World Journal of Gastroenterology : WJG·Animesh JainMark G Lazarev
Citations
Aug 30, 2018·Current Opinion in Gastroenterology·Spyros I Siakavellas, Giorgos Bamias
Oct 5, 2018·Modern Rheumatology·Kei OhnumaChikao Morimoto
Nov 20, 2019·Expert Opinion on Drug Safety·Icilio Cavero, Henry H Holzgrefe
Dec 10, 2019·Rheumatology·Hajir IbraheimNick Powell
Apr 17, 2020·Histopathology·Clarissa A CassolChristina A Arnold
Mar 4, 2019·International Journal of Colorectal Disease·Fiorella CañeteEugeni Domènech
Jun 27, 2019·The AAPS Journal·Mohammad JafarnejadAleksander S Popel
Apr 8, 2020·BMJ : British Medical Journal·Karmela K Chan, Anne R Bass
Feb 9, 2021·American Journal of Clinical Pathology·Ying-Chun LoMarie E Robert
Oct 16, 2020·Clinical Journal of Gastroenterology·Atsuto KayashimaTakanori Kanai
Apr 2, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Seiichi YanoYoshihiro Ogawa
Mar 30, 2021·Scandinavian Journal of Gastroenterology·Britt RoosenboomEllen G van Lochem
Feb 3, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael CollinsFranck Carbonnel
May 1, 2021·Pharmaceuticals·Carmen PortenkirchnerKaroline Horisberger
Aug 3, 2021·Virchows Archiv : an International Journal of Pathology·Sara Hone LopezJacco J de Haan
Aug 5, 2021·Journal of Crohn's & Colitis·Roger FeakinsMonika Tripathi