Histopathological and ultrastructural alterations in the aorta in experimental Solanum malacoxylon poisoning

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
S De BarrosJ A Grimaud

Abstract

A histopathological and electron microscopic study of the aortic wall of rabbits intoxicated with Solanum malacoxylon was performed. Histological examination showed local loss of the normal waviness of the elastic fibers and calcium deposits. Electron microscopic study of the corresponding areas showed a modified aspect of the smooth muscle cells with loss of some of their differential characteristics, especially their intracytoplasmic fibrils and densifications. The neighbouring elastic fibers showed an electron-dense peripheral band and sometimes a crystal deposit. X-ray microanalysis revealed the presence of a large amount of calcium in these crystals. Collagen fibers played no apparent role in this calcification. These findings support the idea that a local cellular alteration is necessary prior to elastic calcification. Two hypothetical mechanisms are proposed.

References

May 1, 1977·Journal of the American Geriatrics Society·T Ishii
Mar 1, 1976·The Journal of Cell Biology·A S NarayananD L Layman
Apr 1, 1963·Journal of Gerontology·S Y YU, H T BLUMENTHAL
Apr 1, 1963·Journal of Gerontology·S Y YU, H T BLUMENTHAL

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Citations

Nov 30, 2002·Toxicon : Official Journal of the International Society on Toxinology·Carlos Hubinger TokarniaPaulo Vargas Peixoto
Dec 7, 2002·Toxicon : Official Journal of the International Society on Toxinology·J R B Mello

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