PMID: 2507113Mar 1, 1989Paper

Histopathological and ultrastructural changes of canine tracheo-bronchi and lung parenchyma after smoke inhalation injury

Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns
J Q Shi

Abstract

Thirty four male mongrel dogs weighing 10-14 kg were used and divided into 2 groups, i.e. experimental group (N-22) and control group (N-12). Animals of the experimental group were sacrificed at the end of 2 (N-5), 6 (N-7), and 24 (N-10) hr after injury. Tissue samples were taken from the trachea, right main bronchus and both lungs of both groups for LM; specimens for EM were taken from trachea, right main bronchus, right lobar bronchus, and right lung in experimental (N-20) and control groups (N-8). LM Findings: In experimental group, at 2 hr after injury, there were necrosis, hyperemia, edema and leucocytic infiltration in tracheal and main bronchial walls; and occasionally acute bronchitis, bronchiolitis, and lobular pneumonia were seen. The lesions became more marked and increased in frequency with the passage of time. At 6 hr, intra-alveolar edema as well as perivascular edematous or/and hemorrhagic cuffs were demonstrated and became more prominent at 24 hr. Goblet cells in the tracheo-bronchial mucosae showed increase in number. EM Findings: At 2 hr post-injury, there was interstitial edema of the thick portions of alveolar septa, presence of platelets and/or leucocytes in the lumina of capillaries, and slight intracellul...Continue Reading

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