Histopathological and ultrastructural studies of a mouse lung model of Campylobacter jejuni infection

Journal of Medical Microbiology
Nadia A Al-BannaM John Albert

Abstract

Campylobacter jejuni is a major cause of diarrhoea in humans. However, the pathogenesis of C. jejuni diarrhoea is poorly understood due to the lack of a good animal model of infection. Many animals have been tried with limited success, but a mouse lung model of infection has been found to be satisfactory previously; however, the lung pathology of this model has not been studied. For the purpose of characterizing the histopathological and ultrastructural lesions in the lung of the mouse pulmonary model of C. jejuni infection, C. jejuni strain 81-176 or sterile PBS was intranasally inoculated into BALB/c mice. The infection resulted in a mild illness only, and in an initial predominance of polymorphonuclear cells, followed by the accumulation of macrophages and later the prominence of epithelioid cells. Focal peribronchial pneumonia appeared on day 3, granuloma-like reaction on day 4 and bronchopneumonia on day 5 post-infection. These features developed until day 5 post-infection, but were less consistent afterwards when histopathology was monitored up to 9 days post-infection. Intracellular structures resembling bacteria were observed on days 3 and 5 post-infection, but not on day 7 post-infection. On days 3 and 5 post-infection...Continue Reading

References

Mar 1, 1979·Acta paediatrica Scandinavica·M MäkiT Vesikari
Mar 1, 1988·The Journal of Infectious Diseases·R E BlackM J Blaser
May 17, 1985·JAMA : the Journal of the American Medical Association·G S Smith, M J Blaser
Sep 1, 1985·The Journal of Infectious Diseases·J A KorlathR A Robinson
Feb 1, 1983·Infection and Immunity·M J BlaserW L Wang
Jan 1, 1994·Microbiology and Immunology·P L PancorboG Alvarez de Cienfuegos
Dec 13, 1997·The Journal of Infectious Diseases·M J Blaser
Dec 24, 1997·Medical Microbiology and Immunology·T M WassenaarA Lastovica
May 30, 1998·Microbial Pathogenesis·D VuckovićM Dorić
Sep 15, 1998·Journal of Medical Microbiology·A E HodgsonS A Leach
Aug 12, 1999·Current Microbiology·P L PancorboG Alvarez de Cienfuegos
Aug 26, 2000·International Journal of Medical Microbiology : IJMM·A EssigR Marre
Jun 26, 2001·Symposium Series·A H van Vliet, J M Ketley
Dec 1, 2001·International Journal of Medical Microbiology : IJMM·E M NielsenV Fussing
May 17, 2002·Current Opinion in Infectious Diseases·Raymond S W Tsang
May 7, 2003·Applied and Environmental Microbiology·Philip F MixterMichael E Konkel
May 6, 2004·Scandinavian Journal of Rheumatology·T HannuM Kauppi
Dec 30, 2006·Infection and Immunity·Robert O WatsonJorge E Galán

❮ Previous
Next ❯

Citations

Feb 28, 2013·International Journal of Experimental Pathology·Regina SordiJamil Assreuy
Nov 22, 2013·Pathogens and Disease·Michael L FisherRoy Curtiss
Jun 6, 2018·Anatomia, histologia, embryologia·Lara Carolina MarioMaria A Miglino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Campylobacteriosis

Campylobacteriosis is caused by the bacteria Campylobacter jejuni and is a common cause of gastroenteritis in humans. Discover the latest research on Campylobacteriosis here.

Campylobacteriosis (ASM)

Campylobacteriosis is caused by the bacteria Campylobacter jejuni and is a common cause of gastroenteritis in humans. Discover the latest research on Campylobacteriosis here.

Related Papers

Methods in Molecular Biology
Martin StahlBruce A Vallance
Duodecim; lääketieteellinen aikakauskirja
A PönkäT Kosunen
Boletín médico del Hospital Infantil de México
A Zamora-ChávezM L Ramírez-Aguilar
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Shahida BaqarJ R Murphy
© 2021 Meta ULC. All rights reserved