Histopathological aspects of transitional cell carcinoma of the bladder: analysis of 20 years experience

International Journal of Urology : Official Journal of the Japanese Urological Association
Alessandro SciarraFranco Di Silverio

Abstract

In this study we used histopathological examinations performed over a 20-year period to describe the characteristics of newly diagnosed transitional cell carcinoma (TCC) of the bladder in relation to patient age, and to verify changes in the TCC over different periods of observation or in relation to patient age. We reviewed all histopathological examinations performed from January 1979 to December 1998 in patients undergoing surgery who were newly diagnosed with TCC of the bladder. All examinations were performed by the same pathologist and reviewed by two pathologists. In each case analyzed, we evaluated T classification of the tumor, histological grade, size, localization, growth type, multiplicity and carcinoma in situ (CIS). The study population included 3113 men and 620 women. The mean patient age was 66.31 +/- 10.84 years. A high percentage of Ta (52.2%) and T1 (27.7%) tumors were found. The number of cases observed and, in particular, the percentage of Ta tumors increased significantly and progressively from the first (1979-1983 = 376 cases; Ta = 37.8%) to the last (1994-1998 = 1732 cases; Ta = 56.3%) period of observation (P < 0.001). A significant difference in the distribution of histological grade and T classificati...Continue Reading

References

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Citations

May 3, 2007·Cell Proliferation·M M NguyenE A Kurzrock
May 3, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Hangchuan ShiXiaoping Zhang
Jun 21, 2015·International Journal of Surgical Pathology·Guang-Qian Xiao, Hani Rashid
Jun 22, 2012·Expert Review of Anticancer Therapy·Daniele CalistriDino Amadori
Nov 14, 2013·Journal of Proteome Research·Navneeta BansalSudhir Kumar Mandal
Sep 21, 2011·Urologic Oncology·Matthew E HyndmanTrinity J Bivalacqua

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