Histopathological changes and lipid metabolism in the liver of Bufo gargarizans tadpoles exposed to Triclosan

Chemosphere
Lihong ChaiHongyuan Wang

Abstract

In the current study, the adverse effects of TCS on liver health of B. gargarizans tadpoles were assessed. B. gargarizans larvae were exposed to TCS at 0, 10, 30, 60, and 150 μg L(-1) from Gosner stage 3 until metamorphic climax. The hepatosomatic index (HSI), hepatic histological and ultrastructural features, and transcript levels of genes associated with detoxification and oxidative stress as well as lipid metabolism in the livers were determined. Exposure to 150 μg L(-1) TCS resulted in increased HSI of tadpoles at metamorphic climax. Histological changes characterized by an increase in the number of melanomacrophage, nucleus pyknosis, and deposition of collagen fibers were observed in liver at 60 and 150 μg L(-1) TCS. Moreover, marked ultrastructural alterations including high electron dense in mitochondrial matrix and lipid accumulation were also observed. In addition, abundances of transcripts of Cu/Zn superoxide dismutase (SOD), phospholipid hydroperoxide glutathione peroxidase (PHGPx), and heat shock protein 90 (HSP90) were decreased in larvae exposed to 60 and 150 μg L(-1) TCS, while transcript level of HSP90 was increased at 30 μg L(-1) TCS. Also, abundances of transcripts of acetyl-CoA carboxylase (ACC), carnitine pa...Continue Reading

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Citations

Apr 6, 2018·International Journal of Environmental Research and Public Health·María Cecilia García-EspiñeiraJesus Olivero-Verbel
Nov 29, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Lisa M Weatherly, Julie A Gosse
Jun 14, 2019·Oxidative Medicine and Cellular Longevity·Mohammad A Alfhili, Myon-Hee Lee
Nov 25, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mei-Fei YuehRobert H Tukey
Jul 14, 2021·Environmental Science and Pollution Research International·Sunil SharmaArvinder Kaur
Jun 28, 2019·Chemical Research in Toxicology·Vânia Vilas-BoasMathieu Vinken
Jul 24, 2018·Environmental Science & Technology·Lingling HuHuahong Shi
Aug 28, 2021·Environmental Pollution·Saurav KumarChandra Bhushan Kumar
Jul 2, 2021·Environmental Science and Pollution Research International·Lara Salgueiro de GregorioClassius De Oliveira

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