Histopathological changes in the oesophageal mucosa in Egyptian children with corrosive strictures: A single-centre vast experience

World Journal of Gastroenterology : WJG
Ayman EskanderMortada Hf El-Shabrawi

Abstract

The caustic ingestion continues to be a major problem worldwide especially in developing countries. The long-term complications include stricture and increased life time risk of oesophageal carcinoma. Patients suffered from corrosive induced oesophageal strictures have more than a 1000-fold risk of developing carcinoma of the oesophagus. To determine the possibility of oesophageal mucosal dysplasia after prolonged dilatation in post corrosive stricture. This observational study was conducted at the Paediatric Endoscopy Unit in Cairo University Children's Hospital. It included children of both sexes older than 2 years of age who had an established diagnosis of post-corrosive oesophageal stricture and repeated endoscopic dilatation sessions for more than 6 mo. All patients were biopsied at the stricture site after 6 mo of endoscopic dilatation. A histopathological examination of an oesophageal mucosal biopsy was performed for the detection of chronic oesophagitis, inflammatory cellular infiltration and dysplasia. The mean age of the enrolled children was 5.9 ± 2.6 years; 90% of the patients had ingested an alkaline corrosive substance (potash). The total number of endoscopic dilatation sessions were ranging from 16 to 100 with me...Continue Reading

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Citations

Feb 6, 2020·Critical Reviews in Toxicology·Alan H HallBernard Meyer
Sep 14, 2021·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Margaret H CollinsMarc E Rothenberg

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Methods Mentioned

BETA
biopsies
targeted
for
biopsy
light microscopy
imaging technique

Software Mentioned

Statistical Package of Social Sciences
Office Excel
SPSS

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