Histopathological characteristics of small diameter melanocytic naevi

Journal of Clinical Pathology
M Braun-FalcoN Scott McNutt

Abstract

The clinical definition of an atypical naevus ("dysplastic naevus" or "naevus with architectural disorder and cytological atypia of melanocytes") stresses size larger than 5 mm in diameter as a major diagnostic criterion. Because malignant melanomas and their precursors may arise in smaller lesions, a histological study of melanocytic lesions smaller than 4 mm in diameter was conducted to evaluate their histological appearance. Two hundred and sixty one naevi smaller than 4 mm in diameter were collected and characterised by histological examination into benign naevi without architectural disorder and naevi with architectural disorder and mild, moderate, and severe atypical melanocytes according to criteria used on larger lesions. Small melanocytic naevi covered the same complex histological spectrum from benign naevi to severely atypical naevi when compared with larger lesions. A high proportion of small naevi (72%) exhibited features diagnostic for naevi with architectural disorder and cytological atypia. There is a discrepancy between histological and clinically defined atypical naevi. The same generally accepted criteria for the histological diagnosis of atypical naevi should be used for small melanocytic naevi in addition t...Continue Reading

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Citations

Dec 11, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Maria V Abello-PobleteBabar K Rao
Aug 14, 2009·Journal of Cutaneous Pathology·Dara N WakefieldKlaus Sellheyer
Nov 6, 2008·Journal of Cutaneous Pathology·Michael S Rabkin
Jul 21, 2009·Journal of Cutaneous Pathology·Carlos A Torres-CabalaVictor G Prieto
Jun 12, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·L TognettiP Rubegni
Dec 1, 2017·Anais Brasileiros De Dermatologia·Danielle Carvalho QuintellaTullia Cuzzi
Jun 9, 2021·PloS One·Gabriella Campos-do-CarmoLuiz Claudio Santos Thuler

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