Histopathological Correlates of Global and Segmental Left Ventricular Systolic Dysfunction in Experimental Chronic Chagas Cardiomyopathy

Journal of the American Heart Association
Luciano Fonseca Lemos de OliveiraM V Simões

Abstract

Chronic Chagas cardiomyopathy in humans is characterized by segmental left ventricular wall motion abnormalities (WMA), mainly in the early stages of disease. This study aimed at investigating the detection of WMA and its correlation with the underlying histopathological changes in a chronic Chagas cardiomyopathy model in hamsters. Female Syrian hamsters (n=34) infected with 3.5×10(4) or 10(5) blood trypomastigote Trypanosoma cruzi (Y strain) forms and an uninfected control group (n=7) were investigated. After 6 or 10 months after the infection, the animals were submitted to in vivo evaluation of global and segmental left ventricular systolic function by echocardiography, followed by euthanasia and histological analysis for quantitative assessment of fibrosis and inflammation with tissue sampling in locations coinciding with the left ventricular wall segmentation employed at the in vivo echocardiographic evaluation. Ten of the 34 infected animals (29%) showed reduced left ventricular ejection fraction (<73%). Left ventricular ejection fraction was more negatively correlated with the intensity of inflammation (r=-0.63; P<0.0001) than with the extent of fibrosis (r=-0.36; P=0.036). Among the 24 animals with preserved left ventric...Continue Reading

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Citations

Feb 3, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Denise Mayumi TanakaMarcus Vinícius Simões
Sep 21, 2017·BioMed Research International·Minna M D RomanoJosé Antônio Marin-Neto
Apr 28, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Luciano Fonseca Lemos de OliveiraMarcus Vinicius Simões
Aug 12, 2021·Revista Do Instituto De Medicina Tropical De São Paulo·Arthur Lauand VargasMinna Moreira Dias Romano
Sep 19, 2021·The International Journal of Cardiovascular Imaging·Fernando Fonseca França RibeiroMinna Moreira Dias Romano

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Methods Mentioned

BETA
heart collection
sedation
biopsy

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Aperio ImageScope View
GraphPad InStat

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