Histopathological differences between early and old lesions of hyperkeratosis Lenticularis Perstans (Flegel's disease)

The American Journal of Dermatopathology
Ko-ichi AndoYohei Yamauchi

Abstract

A case of hyperkeratosis lenticularis perstans (Flegel's disease) was studied histopathologically comparing early and old lesions. The age of the lesions were judged by both the patient's history and direct observation. The histopathologic and immunophenotypic features of a new lesion were essentially in accordance with previous findings. However, the old lesion had obviously different pathologic features. These included the absence of epidermal atrophy and infiltrate in the upper dermis under the lesion. Ultrastructural studies revealed that the presence of many normal-appearing membrane-coating granules in the keratinocytes of the old lesion, whereas the organelles were not found in the keratinocytes of the early lesion.

References

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Citations

May 19, 2009·Actas dermo-sifiliográficas·Pablo Fernández-CrehuetF M Camacho
Nov 15, 2008·International Journal of Dermatology·Heleen Sterneberg-VosPamela Poblete-Gutierrez
Oct 8, 2016·Journal of Cutaneous Pathology·José Carlos CardosoCatherine M Stefanato
Apr 25, 2019·JAMA Dermatology·Jaime MatarredonaIsabel Valencia Ramírez
May 14, 2020·International Journal of Dermatology·Paolo BortoluzziGianluca Nazzaro
Dec 16, 2011·Anais Brasileiros De Dermatologia·Roberto Rheingantz da Cunha Filho, Hiram Larangeira de Almeida
Jul 14, 2010·International Journal of Dermatology·Susun BellewNarciss Mobini
Aug 22, 2021·Journal of Cutaneous Pathology·Francisco Javier Diaz De La PintaLuis Requena

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