PMID: 20629427Jul 16, 2010Paper

Histopathological evaluation of bone regeneration using human resorbable demineralized membrane

Vojnosanitetski pregled. Military-medical and pharmaceutical review
Zoran TatićMia Rakić

Abstract

Filling a bone defect with bone substitution materials is a therapy of choice, but the infiltration of connective tissue from the mucoperiostal flap may compromise a healing of bone substitutions with bony wall defects. Application of membrane as a barrier is indicated as a solution to this problem. The aim of this study was to show a pathohistological view of bone regeneration and the significance of human resorbable demineralized membrane (HRDM), 200 microns thick in bone regeneration regarding mandibular defects in an experiment on dogs. The experiment was performed on six dogs. Bone defects were created in all six dogs on the right side of the mandible after the elevation of the mucoperiostal flap. One defect was filled with human deproteinised bone (HDB), and in between HDB and soft tissue RHDM of 200 microns thick was placed. In the second defect, used as a control one, only HDB without RHDM was placed. Two dogs were sacrificed two months after the surgery, another two dogs four months after the surgery and the last two dogs six months after the surgery. After that, samples of bone tissue were taken for histopathological analysis. In all the six dogs with defects treated with HDB and RHDM the level of bone regeneration wa...Continue Reading

References

Mar 1, 1996·Clinical Orthopaedics and Related Research·J T Mellonig
Sep 3, 2003·Periodontology 2000·Christoph H F Hämmerle, Ronald E Jung
Oct 31, 2003·Journal of Periodontology·David L CochranGaston N King

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