PMID: 7536262May 1, 1995Paper

Histopathological evaluation of laser thermocoagulation in the human prostate: optimization of laser irradiation for benign prostatic hyperplasia

The Journal of Urology
E OrihuelaM M Warren

Abstract

We have previously shown in a canine prostate model that a noncontact low power neodymium:YAG laser regimen of 15 watts for 180 seconds yields a larger volume of coagulation necrosis than the currently recommended high power regimen of 50 watts for 60 seconds. These 2 regimens have not yet been compared in humans. The objective of this study was to evaluate histopathologically the thermocoagulation effect of these 2 laser regimens in the human prostate and the effect of the spatial distribution of the laser lesions on the extent of coagulation necrosis. The study was conducted in 10 patients undergoing radical prostatectomy or cystoprostatectomy. The laser treatment was given transurethrally 1 hour before removal of the specimen. There were no fractures of the prostate. The coagulation necrosis did not reach the peripheral zone and it was minimal in areas rich in fibromuscular tissue, such as the bladder neck. At times, nodular benign prostatic hyperplasia was unaffected. A 4-quadrant treatment in the same plane often yielded small nonconfluent lesions. Confluent lesions in the same plane yielded approximately 30% greater depth of coagulation necrosis, which was achieved when 3 or 4 lesions were created on each side of the pros...Continue Reading

References

Jun 1, 1992·British Journal of Urology·A J CostelloJ Burt
Jan 1, 1992·Lasers in Surgery and Medicine·D E JohnsonD M Cromeens
Jan 1, 1985·Experimental Eye Research·I GriersonA Ahmed
Jan 1, 1973·Scandinavian Journal of Urology and Nephrology·T B Harbitz
Jan 1, 1994·Lasers in Surgery and Medicine·J N Kabalin, H S Gill

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